About the Center

Color coding of many types of cells in the muscle wall of the gastrointestinal tract illustrates the shape and orientation of the cells' nuclei.
Image of color coding of many types of cells in the muscle wall of the gastrointestinal tract illustrates the shape and orientation of the cells' nuclei.

Color coding of many types of cells in the muscle wall of the gastrointestinal tract illustrates the shape and orientation of the cells' nuclei. Image from Simon J Gibbons and Gianrico Farrugia. Principal component analysis courtesy of the Mayo Biomedical Imaging Resource.

The Mayo Clinic Center for Cell Signaling in Gastroenterology (C-SiG) is one of 17 such centers funded through the National Institutes of Health (NIH) Silvio O. Conte Digestive Diseases Research Core Centers (DDRCC) P30 grant mechanism.

The center goals are to support and enhance digestive disease research by:

  • Fostering collaborative, multidisciplinary research both by expanding the technical and collaborative capabilities of established GI scientists and by attracting investigators from other disciplines.
  • Promoting synergistic interaction among Mayo investigators through activities that support digestive disease-related research and promote translation of basic science discoveries into clinical research.
  • Developing and implementing a robust and diverse Scientific Enrichment Program that includes seminars, workshops, symposia and Web-based curricula.
  • Identifying and nurturing development of new GI investigators via a rigorously peer-reviewed Pilot and Feasibility Project Program.
  • Creating a supportive infrastructure that makes technologies more easily accessible, provides technical expertise to members from experts in a particular technology, uses existing resources efficiently, and develops novel methodologies through three linked biomedical center cores.
    • Clinical Core: Offers centralized access for biospecimen acquisition, processing and annotated data.
    • Genetics and Model Systems Core: Provides consultative support at the study design phase for projects involving modern genetics and genomics technologies.
    • Optical Microscopy Core: Provides consultative expertise and training for use of state-of-the art microscopy technologies.