Scanning electron micrograph of cilated cholangiocytes lining each liver cyst in an autosomal recessive polycystic kidney disease animal model.
The Mayo Clinic Center for Cell Signaling in Gastroenterology's (C-SiG) mission is to improve understanding of the signaling pathways that control the function of gastrointestinal cells in health and disease.
While throughout the last decade there has been tremendous progress towards uncovering the fundamental mechanisms contributing to gastrointestinal diseases, new insights have not been sufficiently translated into innovative therapies. Unlike breakthroughs in other major biomedical fields such as atherosclerosis, advances in gastrointestinal cell biology have had a limited meaningful effect on the natural history or prevalence of many diseases involving the gastrointestinal tract. Our center is designed to facilitate progress, which depends upon access to a variety of tools for basic discoveries and opportunities for translational advances.
This center serves as a "hub" that provides access to state-of-the-art research resources and expertise to multidisciplinary groups of basic scientists and clinical researchers. Although the center's focus is on digestive disease research, its members come from a variety of fields in addition to GI – areas like biochemistry and molecular biology, endocrinology, physiology, immunology, pathology and oncology.
The Mayo Clinic Center for Cell Signaling in Gastroenterology fosters research collaboration between scientists and clinicians, which enables faster translation from the lab to clinical trials and, ultimately, improves digestive disease treatment.