A Study Of Glomerular Filtration Rate Tracer Agent Relmapirazin (MB-102)
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 25-014323
About this study
The purpose of this study is to asess agreement and accuracy between transdermal GFR (tGFR) measured with the MB-102/MediBeacon tGFR system and reference GFR measured by iothalamate plasma clearance in the renal lab in patients with known normal kidney function, chronic kidney disease, or those without known kidney disease status.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
Age ≥ 18 years
Patients weighing >55 kilograms
Admitted to ICU OR scheduled for cardiac or major non-cardiac surgeries/ACS-PCI with inpatient monitoring and anticipated stay ≥24 hours.
Baseline GFR ≥15 ml/min/1.73 m2
Able to provide informed consent themselves or their LAR (if they have no capacity).
Adequate venous access for tracer injection
Exclusion Criteria:
Patients with AKI at the time of enrollment
Those on RRT (CRRT, IHD), or planned initiation of RRT within 24 hours of enrollment.
Anuric patients
Known allergy to Lumitrace or similar products.
Severe skin conditions at the sensor site (extensive burns, tattoos, and adhesive allergy).
Known pregnancy or lactation.
Non-English speakers
Prisoners and vulnerable adults
Note: Other protocol defined Inclusion/Exclusion Criteria may apply.
Eligibility last updated 08/12/2026. Questions regarding updates should be directed to the study team contact.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
More information
Publications
Publications are currently not available