Inclusion Criteria:

• Subject is ≥ 40 years of age at the time of enrollment. 
• Subject presents for a screening colonoscopy per standard of care. 
• Subject has no symptoms or signs that require immediate, or near term, referral for diagnostic or therapeutic colonoscopy. 
• Subject is able and willing to sign informed consent.

Exclusion Criteria: 

• Subject has a history of CRC or advanced precancerous lesions. 
• Subject has a diagnosis or medical history of any of the following conditions, including:
  • Familial adenomatous polyposis (also referred to as "FAP", including attenuated FAP and Gardner's syndrome);
  • Hereditary non-polyposis CRC syndrome (also referred to as "HNPCC" or "Lynch Syndrome");
  • Other hereditary cancer syndromes including but are not limited to Peutz-Jeghers Syndrome, MYH-Associated Polyposis (MAP), Turcot's (or Crail's) Syndrome, Cowden's Syndrome, Juvenile Polyposis, Neurofibromatosis, or Familial Hyperplastic Polyposis.
• Subject has a diagnosis or personal history of inflammatory bowel disease (IBD) including chronic ulcerative colitis and/or Crohn's disease. 
• Subject has a diagnosis of Cronkhite-Canada Syndrome. 
• Subject has had a positive Cologuard, or fecal occult blood test or FIT within the previous two (2) years. 
• Subject has undergone a colonoscopy within the previous 9 years. 
• Subject has had overt rectal bleeding within the previous 30 days. 
• Subject has any condition that in the opinion of the Investigator should preclude participation in the study.