A Study of In Vitro Mapping of Cardiac Tissue Obtained from Patients with Refractory Arrhythmias who Underwent Heart Transplant or Replacement with Mechanical Heart


About this study

The purpose of this study is to obtain electro-anatomic maps of human myocardium in sinus rhythm and ventricular arrhythmias to identify activation patterns, identify and perform tissue ablation at targeted sites of interest that could play an important trigger for development of arrhythmias, and to perform histologic analysis of the myocardial tissue to identify triggers and/or targets for therapies to terminate ventricular arrhythmias.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Citeria:

  • Male and female patients of all ages.
  • Life-limiting ventricular arrhythmias that is refractory to therapy.
  • Uderwent heart transplant or replacement with mechanical heart.  

Exclusion Citeria:

  • Patients without family members or legal authorized represenatives.
  • Aility to understand and sign written informed consent forms which must be obtained prior to initiation of study.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Samuel Asirvatham, M.D.

Contact us for the latest status

Contact information:

Omar Yasin M.D., M.S.

(507) 284-0945


More information


Publications are currently not available