A Study to Analyze Association of Frequent Premature Ventricular Complex with Stroke or Transient Ischemic Attack


About this study

The purpose of this study is to verify that high Premature Ventricular Complex (PVC) burden is associated with increased risk of stroke and/or Transient Ischemic Attack (TIA), to examine outcomes such as stroke/TIA, atrial fibrillation/flutter, and all-cause mortality associated with PVCs, and to evaluate whether PVCs are associated with development of appendage dysfunction.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Adult patients, 18 years of age and older.
  • Patients who underwent 24 hour Holter monitoring along with echocardiogram study from January 1995 to December 2015, with or without PVCs.
  • Patients who indicated Yes to MN Research Authorization

Exclusion Criteria:

  • Poor quality Holter testing or incomplete testing.
  • History of cardiomyopathy/valvular/congenital heart disease.
  • History of atrial fibrillation/flutter, malignancy, connective tissue disease.
  • Any major trauma or surgery within the preceding 3 months.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Samuel Asirvatham, M.D.

Contact us for the latest status

Contact information:

Qian Ye M.D.



More information


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