Risk Factors for Exfoliation Syndrome, Exfoliation Glaucoma and Primary Open Angle Glaucoma
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 12-004763
Sponsor Protocol Number: 12-004763
About this study
We are doing this research study to find out the genetic and environmental factors that contribute to glaucoma (high pressure in the eye), which can cause vision loss and blindness if untreated. Exfoliation syndrome is a common condition that can lead to exfoliation glaucoma. The most common form of glaucoma is called primary open angle glaucoma. Identifying the factors that lead to exfoliation syndrome and glaucoma may help us to develop future tests and treatments for these conditions.
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria: Cases
- Exfoliation Syndrome
- Exfoliation Glaucoma
- Angle Closure Glaucoma
- Primary Open Angle Glaucoma
Exclusion Criteria: Cases
- None for exfoliation status but glaucoma not mentioned above will be scored as unknown
- Individuals who have received chronic steroid therapy
Controls:
Individuals will be scored as unaffected if the following criteria are met:
- absence of exfoliation material either at clinical exam or in clinical records,
- IOP without treatment less than 22 mmHg, and
- No evidence of glaucomatous optic nerve disease (symmetric vertical cup to disc ratio of less than 0.6), and
- age >60 as ES is strongly age-related.
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Arthur Sit, M.D., M.S. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available