A Study Using Ultrasound Surface Wave Elastography to Measure Tissue Thickness and Elasticity in Eyes with Glaucoma


About this study

The purpose of this study is to use Ultrasound surface wave elastography to measure and compare the tissue thickness and elasticity in normal eyes and eyes with glaucoma. The goal is to understand the association between tissue characteristics and glaucoma.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria

  • Either gender
  • Any self-declared ethnoracial category
  • Greater than or equal to 18 years of age
  • Ability to cooperate for examinations required for study
  • Normal subjects
    • Healthy eyes with the crystalline lens
    • Without glaucoma (cup:disc ratio < 0.6 both eyes. Asymmetry of cup:disc ratio between eyes < 0.2)
    • Without any other clinically significant eye diseases
    • Open angles
  • Glaucoma patients
    • Newly diagnosed glaucoma patients (POAG, NTG, and pseudoexfoliative glaucoma)
    • Without any previous anti-glaucomatous treatment
    • Medically treated glaucoma patients who can safely stop medication for 6 weeks
      • MD > -10dB on standard automated perimetry
      • No central scotoma
      • Pre-treatment IOP ≤ 35 mmHg
      • Using two or less medications

Exclusion Criteria

  • Chronic or recurrent inflammatory eye diseases
  • Ocular trauma within the past 6 months
  • Ocular infection or ocular inflammation in the past 3 months
  • Clinically significant retinal disease
  • Cornea pathologic changes preventing reliable measurement (scarring, opacity)
  • Previous intraocular surgery
  • Previous corneal refractive surgeries
  • Serious hypersensitivity to topical anesthetic medication

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Arthur Sit, M.D., M.S.

Open for enrollment

Contact information:

Jessica Morgan C.O.A.

(507) 293-9689


More information


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