A Study to Measure the Connection of Cause and Effect in Muscle Contraction, and Changes Caused by Aging


  • Study type

  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 14-000222
    Sponsor Protocol Number: 14-000222

About this study

The purpose of this study is to learn about and measure changes in muscle contraction that happen as healthy people age. The connection between electrical activity causing muscles to contract and the pressure created as muscles contract will be studied.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria

  • Twelve healthy, young individuals between the ages of 21 and 40 years
  • Twelve healthy, older adults between the ages of 60 to 80 years of age
  • Good neuromuscular health
  • Women of childbearing potential are included in the subject population

Exclusion Criteria

  • History of central or peripheral nervous system disorders, myopathy, or musculoskeletal pathology
  • Current use of medications that affect muscle strength (e.g. corticosteroids, statins)
  • History of surgery of the lower extremities
  • Bleeding disorders
  • Current use of blood-thinning medications
  • Women who are pregnant will also be excluded from this study.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Kenton Kaufman, Ph.D.

Open for enrollment

Contact information:

Swati Chopra Ph.D.