Publications

  1. Ek WE, Reznichenko A, Ripke S, Niesler B, Zucchelli M, Rivera NV, Schmidt PT, Pedersen NL, Magnusson P, Talley NJ, Holliday EG, Houghton L, Gazouli M, Karamanolis G, Rappold G, Burwinkel B, Surowy H, Rafter J, Assadi G, Li L, Papadaki E, Gambaccini D, Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. Gut. 2014 Sep 23.
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  2. Qumseya BJ, Tayem Y, Almansa C, Dasa OY, Hamadneh MK, Al-sharif AF, Hmidat AM, Abu-limon IM, Nahhal KW, Alassas K, DeVault K, Wallace MB, Houghton LA. Irritable bowel syndrome in middle-aged and elderly Palestinians: its prevalence and effect of location of residence. Am J Gastroenterol. 2014 May; 109(5):723-39. Epub 2014 Mar 04.
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  3. Veiga P, Pons N, Agrawal A, Oozeer R, Guyonnet D, Brazeilles R, Faurie JM, van Hylckama Vlieg JE, Houghton LA, Whorwell PJ, Ehrlich SD, Kennedy SP. Changes of the human gut microbiome induced by a fermented milk product. Sci Rep. 2014; 4:6328. Epub 2014 Sep 11.
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  4. Shekhar C, Monaghan PJ, Morris J, Issa B, Whorwell PJ, Keevil B, Houghton LA. Rome III functional constipation and irritable bowel syndrome with constipation are similar disorders within a spectrum of sensitization, regulated by serotonin. Gastroenterology. 2013 Oct; 145(4):749-57; quiz e13-4. Epub 2013 Jul 19.
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  5. Abdulqawi R, Houghton LA, Smith JA. Gastro-oesophageal reflux and cough. J Assoc Physicians India. 2013 May; 61(5 Suppl):17-9.
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  6. Almansa C, Agrawal A, Houghton LA. Intestinal microbiota, pathophysiology and translation to probiotic use in patients with irritable bowel syndrome. Expert Rev Gastroenterol Hepatol. 2012 Jun; 6(3):383-98.
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  7. Decalmer S, Stovold R, Houghton LA, Pearson J, Ward C, Kelsall A, Jones H, McGuinness K, Woodcock A, Smith JA. Chronic cough: Relationship between microaspiration, gastroesophageal reflux, and cough frequency. Chest. 2012; 142(4):958-64.
  8. Smith JA, Abdulqawi R, Houghton LA. GERD-related cough: pathophysiology and diagnostic approach. Curr Gastroenterol Rep. 2011 Jun; 13(3):247-56.
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  9. Kelsall A, Houghton LA, Jones H, Decalmer S, McGuinness K, Smith JA. A novel approach to studying the relationship between subjective and objective measures of cough. Chest. 2011 Mar; 139(3):569-75. Epub 2010 Sep 23.
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  10. Houghton LA. Bloating in constipation: relevance of intraluminal gas handling. Best Pract Res Clin Gastroenterol. 2011 Feb; 25(1):141-50.
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  11. Gale J, Houghton LA. Do alpha2delta lligands provide a way forward in the treatment of irritable bowel syndrom? Frontiers in Gastrointestinal Pharmacology. 2011; 2(28).
  12. Smith JA, Decalmer S, Kpmes H, Kelsall A, McGuiness K, Jones H, Galloway S, Woodcock A, Houghton LA. Acoustic Cough—Reflux Associations in Chronic Cough: Potential Triggers and Mechanisms. Gastroenterology. 2010 Sep; 138(3):754-62.
  13. Sanger GJ, Chang L, Bountra C, Houghton LA. Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders. Therap Adv Gastroenterol. 2010 Sep; 3(5):291-305.
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  14. Houghton LA. Bloating and distension in irritable bowel syndrome: recent advances, speculations and possible implications for future treatment. Annals of Gastroenterology and Hepatology. 2010; 1:25-35.
  15. Niesler B, Fell C, Kapeller J, Atkinson W, Moller D, Cox V, Fischer C, Whorwell PJ, Rappoid G, Houghton LA. SERT-P and VNTR polymorphism in the serotonin transporter gene and irritable bowel syndrome effect of bowel habit and gender. European J of Gastroenterology and Hepatology. 2010(7):856-61.
  16. Smith J, Woodcock A, Houghton LA. New developments in reflux-associated cough. Lung. 2009 Epub 0.
  17. Monaghan P, Brown HA, Houghton LA, Keevil BG. Measurement of serotonin in platelet depleted plasma by liquid chromatography tandem mass spectrometry. J Chromatography B Analyt Technol Biomed Life Sci. 2009; 877:2163-7.
  18. Agrawal A, Houghton LA, Morris J, Reilly B, Whorwell PJ. Bloating and sistension in irritable bowel syndrome: the role of gastrointestinal transit. Am J Gastroenterology 2009 04. 2009; 104(8):1998-2004.
  19. Houghton LA, Brown H, Atkinson W, Morris J, Fell C, Whorwell PJ, Lockhard S, Keevil B. 5-hydroxytrptyamine signaling in irritable bowel syndrome with diarrhoea effects of gender and menstrual status. Alimentary Pharmacology and Therapeutics. 2009; 30(9):919-929.
  20. Kapeller J, Houghton LA, Monnikes H, Walstab J, Moller D, Bonisch H, Burwinkel B, Autschbach F, Funke B, Lasitschka F, Gassler N, Fischer C, Whorwell PJ, Atkinson W, Fell C, Buchner KJ, Schmidtmann M, van der Voort I, Wisser AS, Berg T, Rappold G, First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome. Hum Mol Genet. 2008 Oct 1; 17(19):2967-77. Epub 2008 Jul 09.
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  21. Agrawal A, Houghton LA, Morris J, Reilly B, Guyonnet D, Goupil Feuillerat N, Schlumberger A, Jakob S, Whorwell PJ. Clinical trial: The effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation. Aliment Pharmacol Ther. 2008 Sep 17. [Epub ahead of print]
  22. Agrawal A, Houghton LA, Lea R, Morris J, Reilly B, Whorwell PJ. Bloating and distention in irritable bowel syndrome: the role of visceral sensation. Gastroenterology. 2008 Jun; 134(7):1882-9. Epub 2008 Mar 08.
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  23. Agrawal A, Houghton LA, Lea R, Reilly B, Whorwell PJ. Abdominal bloating and distension in irritable bowel syndrome: a role for visceral sensation. Gastroenterology. 2008; 134:1882-9.
  24. Spiller R, Aziz Q, Creed F, Emmanuel A, Houghton LA, Hungin P, Jones R, Kumar D, Rubin G, Trudgill N, Whorwell PJ. Guidelines on the Irritable Bowel Syndrome: mechanisms and practical management. Gut. 2007; 56:1770-98.
  25. Houghton LA, Atkinson W, Lockhart S, Fell C, Whorwell PJ, Keevil B. Increased colonic motility in patients with irritable bowel syndrome: a role for 5-hydroxytryptamine. Neurogastroenterol Motil. 2007; 19:724-31.
  26. Houghton LA, Fell C, Whorwell PJ, Jones I, Sudworth DP, Gale JD. Effect of a second generation α2δ ligand, pregabalin on visceral sensation: a randomized controlled pilot study. Gut (see Camilleri commentary. 2007 56: 1337-1338) 2007; 56:1218-25.
  27. Houghton LA, Cremonini F, Camilleri M, Ferber I, Fell C, Cox V, Castillo EJ, Lea R, Zinsmeister AR, Whorwell PJ. Effect of the NK3 receptor antagonist, Talnetant on rectal sensory function and compliance in healthy humans. Neurogastroenterol Motil. 2007; 19:732-43.
  28. Longstreth F, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller R. Functional Bowel Disorders.Rome III Gastroenterology. 2006 May; 130(5):1480-91.
  29. McLaughlin J, Houghton LA. The rationale, efficacy and safety evidence for tegaserod in the treatment of irritable bowel syndrome. Expert Opin Drug Saf. 2006; 5(2):313-27.
  30. Tack J, Fried M, Houghton LA, Spicak J. An evidence-based review of the treatments for irritable bowel syndrome: a European persective. Aliment Pharmacol Ther. 2006; 24:183-205.
  31. Houghton LA, Atkinson W, Whorwell PJ, Morris J, Murdoch R, Cooper SM, Webber D, Walls C. Single-centre, randomized, double-blind, placebo-controlled, two-part crossover studies to investigate the effect of cilomilast, a selective phosphodiesterase 4 (PDE 4) inhibitor, on oesophageal motility and pH, and orocaecal and colonic transit in health y volunteers. Clin Ther. 2006; 28(No 4):569-81.
  32. Atkinson W, Lockhart SJ, Houghton LA, Keevil BG. Validation of the measurement of low concentrations of 5-hydroxytryptamine (5-HT) in plasma using high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2006; 832(1):173-6.
  33. Houghton LA, Lea R, Agrawal A, Reilly B, Whorwell PJ. Relationship of bloating to abdominal distension in the irritable bowel syndrome and effect of bowel habit. Gastroenterology. 2006; 131:1003-10.
  34. Atkinson W, Lockhart S, Whorwell PJ, Keevil B, Houghton LA. Altered 5-hydroxytryptamine signaling in patients with constipation and diarrhoea predominant irritable bowel syndrome. Gastroenterology (See Camilleri commentary) 2006; 130:34-43.
  35. Cremonini F, Houghton LA, Camilleri M, Ferber I, Fell C, Cox V, Castillo EJ, Alpers DH, Dewit OE, Gray E, Lea R, Zinsmeister AR, Whorwell PJ. Barostat testing of rectal sensation and compliance in humans: comparison of results across two centres and overall reproducibility. Neurogastroenterology & Motility. 2005 Dec; 17(6):810-20.
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  36. Houghton LA, Whorwell PJ. Towards a better understanding of abdominal bloating and distension in functional gastrointestinal disorders. Neurogastroenterol Motil. 2005; 17:500-11.
  37. Calvert EL, Whorwell PJ, Houghton LA. Inter-digestive and post-prandial antro-pyloro-duodenal motor activity in man: effect of 5-hydroxytryptamine 1 receptor agonism. Aliment Pharmacol Ther. 2004; 19:805-15.
  38. Lea R, Hopkins V, Hastleton J, Houghton LA, Whorwell PJ. Diagnostic criteria for Irritable Bowel Syndrome: Utility and Applicability in Clinical Practice. Digestion. 2004; 70:210-3.
  39. Houghton LA, Atkinson W, Whitaker P, Whorwell PJ, Rimmer M. A role for 5-HT in the post-prandial exacerbation of symptoms in female patients with diarrhoea predominant irritable bowel syndrome Gut. 2003; 52:663-70.
  40. Lea R, Houghton LA, Calvert EL, Larders S, Gonsalkorale W, Whelan V, Randles J, Cooper P, Cruickshanks P, Miller V, Whorwell PJ. Gut focused hypnotherapy normalizes rectal hyper-sensitivity in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2003; 17:635-42.
  41. Houghton LA, Lea R, Jackson N, Whorwell PJ. The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers. Gut. 2002; 50:471-4.
  42. Gonsalkorale WM, Houghton LA, Whorwell PJ. Hypnotherapy in irritable bowel syndrome: a large scale audit of a clinical service with examination of factors influencing responsiveness. Am J Gastroenterology. 2002; 97:954-61.
  43. Houghton LA, Calvert EL, Jackson NA, Cooper P, Whorwell PJ. Visceral sensation and emotion: a study using hypnosis. Gut. 2002; 51:701-4.
  44. Calvert EL, Houghton LA, Cooper P, Morris J, Whorwell PJ. Long-term improvement in functional dyspepsia using hypnotherapy. Gastroenterology. 2002; 123:1778-86.
  45. Reilly B, Bolton M, Houghton LA, Lewis M, Whorwell PJ. A device for 24 hour ambulatory monitoring of abdominal girth using inductive plethysmography. Physiol Meas. 2002; 23:661-70.
  46. Lewis M, Reilly B, Houghton LA, Whorwell PJ. Ambulatory abdominal inductance plethysmography: towards objective assessment of abdominal distension in irritable bowel syndrome. Gut. 2001; 48:216-20.
  47. Houghton LA, Jackson NA, Whorwell PJ, Morris J. Do male sex hormones protect from the irritable bowel syndrome? Am J Gastroenterology. 2000; 95(9):2296-300.
  48. Houghton LA, Foster J, Whorwell PJ. Alosetron delays left colonic transit in healthy volunteers and patients with irritable bowel syndrome. Aliment Pharmacol Ther. 2000; 14:775-8.
  49. Foster JM, Houghton LA, Whorwell PJ. Altered oesophageal motility following administration of the 5-HT1 agonist, sumatriptan. Aliment Pharmacol Ther. 1999; 13:927-36.
  50. Houghton LA, Jackson NA, Whorwell PJ, Cooper S. 5-HT4 receptor antagonism in irritable bowel syndrome: effect of SB-207266-A on rectal sensitivity and small bowel transit. Aliment Pharmacol Ther. 1999; 13:1437-44.
  51. Gonsalkorale WM, Houghton LA, Whorwell PJ. Physiological and psychological aspects of irritable bowel syndrome and role of hypnosis. Gastroenterology International. 1998; 11:36-44.
  52. Houghton LA, Rogers J, Whorwell PJ, Campbell FC, Raimundo A, Goka J. Zamifenacin, a new potent M3 muscarinic antagonist, reduces colonic motility in patients with irritable bowel syndrome. Aliment Pharmacol Ther. 1997; 11:561-8.
  53. Houghton LA, Whorwell PJ. Opening the doors of perception in the irritable bowel syndrome. Commentary Gut. 1997; 41:567-8.
  54. Houghton LA, Heyman DJ, Whorwell PJ. Symptomatology, quality of life and economic features of irritable bowel syndrome: the effect of hypnotherapy. Aliment Pharmacol Ther. 1996; 10:91-5.
  55. Houghton LA, Wych J, Whorwell PJ. Acute diarrhoea induces rectal sensitivity in women but not men. Gut. 1995; 37:270-4.
  56. Francis CY, Houghton LA. Use of hypnotherapy in gastrointestinal disorders. Eur J Gastroenterol Hepatol. 1995; 8:525-9.
  57. Mangnall YF, Houghton LA, Johnson AG, Read NW. Abnormal distribution of a fatty test meal within the stomach of patients with functional dyspepsia. Eur J Gastroenterol Hepatol. 1994; 6:323-7.
  58. Jackson NA, Houghton LA, Whorwell PJ. Does the menstrual cycle affect anorectal physiology? Dig Dis Sci. 1994; 39:2607-11.
  59. Houghton LA, Prior A, Whorwell PJ. Effect of acute mental and physical stress on anorectal physiology in normal healthy volunteers. Eur J Gastroenterol Hepatol. 1994; 6:389-92.
  60. Taylor EE, Houghton LA, Whorwell PJ. Hypnotherapy in achalasia: a case report. J Clin Hypnotherapy and hypnoanalysis. 1994; 23.
  61. Houghton LA, Foster J, Whorwell PJ, Morris J, Fowler P. Cause of chest pain after sumatriptan: Is it oesophageal? Lancet. 1994; 344:985-6.
  62. Houghton LA, Mangnall YF, Dwivedi A, Read NW. Sensitivity to nutrient ingestion in patients with non-ulcer dyspepsia. Eur J Gastroenterol Hepatol. 1993; 5(No 2):109-13.
  63. Whorwell PJ, Houghton LA, Taylor EE, Maxton DG. Physiological effects of emotion: a study via hypnosis. Lancet. 1992; 340:69-72.
  64. Houghton LA, Fowler P, Keene ON, Read NW. The effect of a new selective 5HT1 - like agonist, sumatriptan (GR43175) on the rate of gastric emptying of a liquid test meal in man. Aliment Pharmacol Ther. 1992; 6:685-92.
  65. Kerrigan DD, Read NW, Houghton LA, Taylor ME, Johnson AG. Disturbed gastroduodenal motility in patients with active and healed duodenal ulceration. Gastroenterology. 1991; 100:892-900.
  66. Collins PJ, Houghton LA, Read NW, Horowitz M, Chatterton BE, Heddle R, Dent J. Role of the proximal and distal stomach in mixed solid and liquid emptying. Gut. 1991; 32:615-9.
  67. Houghton LA, Read NW, Heddle R, Dent J. Relationship between fluctuations of pH and pressure in the human stomach and duodenum. Dig Dis Sci. 1990; 8(Suppl 1):71-81.
  68. Houghton LA, Mangnall YF, Read NW. Effect of incorporating fat into a liquid test-meal on the relationship between intragastric distribution and gastric emptying in human volunteers. Gut. 1990; 31:1226-9.
  69. Houghton LA, Kerrigan DD, Read NW. Effect of intragastric infusion of acid on the antropyloroduodenal motor unit in human volunteers. Neurogastroenterol Motil. 1990; Vol 2(No 3):202-8.
  70. Heddle R, Collins PJ, Dent J, Horowitz M, Read NW, Chatterton BE, Houghton LA. Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion. Eur J Gastroenterol Hepatol. 1989; 4:437-47.
  71. Kerrigan DD, Read NW, Taylor ME, Houghton LA, Johnson AG. Duodenal bulb acidity and the natural history of duodenal ulceration. Lancet. 1989; ii:61-2.
  72. Akkermans LMA, Houghton LA, Brown NJ. Neural and hormonal control of pyloric sphincter function. Scand J Gastroenterology. 1989; 24(Suppl 71):27-31.
  73. Heddle R, Dent J, Read NW, Houghton LA, Toouli J, Horowitz M, Downton J. Antropyloroduodenal motor responses to intraduodenal lipid infusion in healthy volunteers. Am J Physiol. 1988; 254:G671-9.
  74. Sun WM, Houghton LA, Read NW, Grundy DG, Johnson AG. Effect of meal temperature on gastric emptying of liquids in humans. Gut. 1988; 29:302-5.
  75. Paraskevopoulus JA, Houghton LA, Eyre-Brook I, Johnson AG, Read NW. Effect of composition of gastric contents on resistance to emptying of liquids from stomach in humans. Dig Dis Sci. 1988; 33:914-8.
  76. Houghton LA, Read NW, Heddle R, Maddern GJ, Downton J, Toouli J, Dent J. Motor activity of the gastric antrum, pylorus and duodenum under fasted conditions and after a liquid meal. Gastroenterology. 1988; 94:1276-84.
  77. Houghton LA, Read NW, Heddle R, Horowitz M, Collins PJ, Chatterton BE, Dent J. Relationship of the motor activity of the antrum, pylorus and duodenum to gastric emptying of a solid-liquid mixed meal. Gastroenterology. 1988; 94:1285-91.
  78. Houghton LA, Read NW, Heddle R, Horowitz M, Dent J. Antroduodenal coordination and solid lag phase. Gastroenterology. 1988; 95:1694.
  79. Houghton LA, Read NW. A comparative study on the effect of H2- receptor antagonists, cimetidine and ranitidine on the rate of gastric emptying of liquid and solid test meals in man. Aliment Pharmacol Ther. 1987; 1:409-14.
  80. Houghton LA, Hickson F, Read NW. Effect of food consistency on gastric emptying in man. Gut. 1987; 28:584-8.