Publications

  1. Dahlin JL, Kottom T, Han J, Zhou H, Walters MA, Zhang Z, Limper AH. Pneumocystis jirovecii Rtt109, a Novel Drug Target for Pneumocystis Pneumonia in Immunosuppressed Humans. Antimicrob Agents Chemother. 2014 Jul; 58(7):3650-9. Epub 2014 Apr 14.
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  2. Onozawa M, Zhang Z, Kim YJ, Goldberg L, Varga T, Bergsagel PL, Kuehl WM, Aplan PD. Repair of DNA double-strand breaks by templated nucleotide sequence insertions derived from distant regions of the genome. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7729-34. Epub 2014 May 12.
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  3. Burgess RJ, Han J, Zhang Z. The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast. J Biol Chem. 2014 Apr 11; 289(15):10518-29. Epub 2014 Feb 25.
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  4. Han J, Zhang H, Zhang H, Wang Z, Zhou H, Zhang Z. A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly. Cell. 2013 Nov 7; 155(4):817-29.
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  5. Zhang H, Wang Z, Zhang Z. PP1alpha, PP1beta and Wip-1 regulate H4S47 phosphorylation and deposition of histone H3 variant H3.3. Nucleic Acids Res. 2013 Sep; 41(17):8085-93. Epub 2013 Jul 04.
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  6. Chan KM, Han J, Fang D, Gan H, Zhang Z. A lesson learned from the H3.3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo? Cell Cycle. 2013 Aug 15; 12(16):2546-52. Epub 2013 Jul 10.
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  7. Chan KM, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, Gupta N, Mueller S, James CD, Jenkins R, Sarkaria J, Zhang Z. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 2013 May 1; 27(9):985-90. Epub 2013 Apr 19.
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  8. Li Q, Burgess R, Zhang Z. All roads lead to chromatin: multiple pathways for histone deposition. Biochim Biophys Acta. 2013 Mar-Apr; 1819(3-4):238-46.
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  9. Burgess RJ, Zhang Z. Histone chaperones in nucleosome assembly and human disease. Nat Struct Mol Biol. 2013 Jan; 20(1):14-22.
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  10. Dahlin JL, Sinville R, Solberg J, Zhou H, Han J, Francis S, Strasser JM, John K, Hook DJ, Walters MA, Zhang Z. A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation. PLoS One. 2013; 8(11):e78877. Epub 2013 Nov 18.
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  11. Liu CP, Xiong C, Wang M, Yu Z, Yang N, Chen P, Zhang Z, Li G, Xu RM. Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Nat Struct Mol Biol. 2012 Dec; 19(12):1287-92. Epub 2012 Nov 11.
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  12. Winkler DD, Zhou H, Dar MA, Zhang Z, Luger K. Yeast CAF-1 assembles histone (H3-H4)2 tetramers prior to DNA deposition. Nucleic Acids Res. 2012 Nov 1; 40(20):10139-49. Epub 2012 Aug 31.
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  13. Chan KM, Zhang Z. Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing. J Biol Chem. 2012 Apr 27; 287(18):15024-33. Epub 2012 Mar 15.
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  14. Weintraub WS, Grau-Sepulveda MV, Weiss JM, O'Brien SM, Peterson ED, Kolm P, Zhang Z, Klein LW, Shaw RE, McKay C, Ritzenthaler LL, Popma JJ, Messenger JC, Shahian DM, Grover FL, Mayer JE, Shewan CM, Garratt KN, Moussa ID, Dangas GD, Edwards FH. Comparative effectiveness of revascularization strategies. N Engl J Med. 2012 Apr 19; 366(16):1467-76. Epub 2012 Mar 27.
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  15. Fazly A, Li Q, Hu Q, Mer G, Horazdovsky B, Zhang Z. Histone chaperone Rtt106 promotes nucleosome formation using (H3-H4)2 tetramers. J Biol Chem. 2012 Mar 30; 287(14):10753-60. Epub 2012 Feb 15.
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  16. Su D, Hu Q, Li Q, Thompson JR, Cui G, Fazly A, Davies BA, Botuyan MV, Zhang Z, Mer G. Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106. Nature. 2012 Mar 1; 483(7387):104-7. Epub 2012 Feb 05.
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  17. Li Q, Burgess R, Zhang Z. All roads lead to chromatin: Multiple pathways for histone deposition. Biochim Biophys Acta. 2012 Mar; 1819(3-4):238-46. Epub 2011 Jul 07.
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  18. Zhang H, Han J, Kang B, Burgess R, Zhang Z. Human histone acetyltransferase 1 protein preferentially acetylates H4 histone molecules in H3.1-H4 over H3.3-H4. J Biol Chem. 2012 Feb 24; 287(9):6573-81. Epub 2012 Jan 07.
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  19. Li Q, Zhang Z. Linking DNA replication to heterochromatin silencing and epigenetic inheritance. Acta Biochim Biophys Sin (Shanghai). 2012 Jan; 44(1):3-13.
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  20. Burgess RJ, Zhou H, Han J, Li Q, Zhang Z. The SCFDia2 ubiquitin E3 ligase ubiquitylates Sir4 and functions in transcriptional silencing. PLoS Genet. 2012; 8(7):e1002846. Epub 2012 Jul 26.
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  21. Chan KM, Zhang H, Malureanu L, van Deursen J, Zhang Z. Diverse factors are involved in maintaining X chromosome inactivation. Proc Natl Acad Sci U S A. 2011 Oct 4; 108(40):16699-704. Epub 2011 Sep 21
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  22. Lau AT, Lee SY, Xu YM, Zheng D, Cho YY, Zhu F, Kim HG, Li SQ, Zhang Z, Bode AM, Dong Z. Phosphorylation of histone H2B serine 32 is linked to cell transformation. J Biol Chem. 2011 Jul 29; 286(30):26628-37. Epub 2011 Jun 06.
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  23. Kang B, Pu M, Hu G, Wen W, Dong Z, Zhao K, Stillman B, Zhang Z. Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly. Genes Dev. 2011 Jul 1; 25(13):1359-64.
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  24. Kottom TJ, Han J, Zhang Z, Limper AH. Pneumocystis carinii expresses an active Rtt109 histone acetyltransferase. Am J Respir Cell Mol Biol. 2011 Jun; 44(6):768-76. Epub 2010 Jul 23.
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  25. Su D, Hu Q, Zhou H, Thompson JR, Xu RM, Zhang Z, Mer G. Structure and histone binding properties of the Vps75-Rtt109 chaperone-lysine acetyltransferase complex. J Biol Chem. 2011 May 6; 286(18):15625-9. Epub 2011 Mar 22.
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  26. Li Q, Zhang Z. Linking DNA replication to heterochromatin silencing and inheritance. ABBS. 2011.
  27. Burgess RJ, Zhang Z. Roles for Gcn5 in promoting nucleosome assembly and maintaining genome integrity. Cell Cycle. 2010 Aug 1; 9(15):2979-85. Epub 2010 Aug 23.
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  28. Han J, Li Q, McCullough L, Kettelkamp C, Formosa T, Zhang Z. Ubiquitylation of FACT by the cullin-E3 ligase Rtt101 connects FACT to DNA replication. Genes Dev. 2010 Jul 15; 24(14):1485-90.
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  29. Burgess RJ, Zhang Z. Histones, histone chaperones and nucleosome assembly. Protein Cell. 2010 Jul; 1(7):607-12.
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  30. Burgess RJ, Zhou H, Han J, Zhang Z. A role for Gcn5 in replication-coupled nucleosome assembly. Mol Cell. 2010 Feb 26; 37(4):469-80.
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  31. Falbo KB, Alabert C, Katou Y, Wu S, Han J, Wehr T, Xiao J, He X, Zhang Z, Shi Y, Shirahige K, Pasero P, Shen X. Involvement of a chromatin remodeling complex in damage tolerance during DNA replication. Nat Struct Mol Biol. 2009 Nov; 16(11):1167-72. Epub 2009 Oct 25.
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  32. Li Q, Fazly AM, Zhou H, Huang S, Zhang Z, Stillman B. The elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents. PLoS Genet. 2009 Oct; 5(10):e1000684. Epub 2009 Oct 16.
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  33. Yuan J, Pu M, Zhang Z, Lou Z. Histone H3-K56 acetylation is important for genomic stability in mammals. Cell Cycle. 2009 Jun 1; 8(11):1747-53. Epub 2009 Jun 03.
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  34. Burgess R, Jenkins R, Zhang Z. Epigenetic changes in gliomas. Cancer Biol Ther. 2008 Sep; 7(9):1326-34. Epub 2008 Sep 18.
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  35. Li Q, Zhou H, Wurtele H, Davies B, Horazdovsky B, Verreault A, Zhang Z. Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly. Cell. 2008 Jul 25; 134(2):244-55.
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  36. Han J, Zhou H, Li Z, Xu RM, Zhang Z. Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity. J Biol Chem. 2007 Sep 28; 282(39):28587-96. Epub 2007 Aug 09.
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  37. Han J, Zhou H, Li Z, Xu RM, Zhang Z. The Rtt109-Vps75 histone acetyltransferase complex acetylates non-nucleosomal histone H3. J Biol Chem. 2007 May 11; 282(19):14158-64.
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  38. Huang S, Zhou H, Tarara J, Zhang Z. A novel role for histone chaperones CAF-1 and Rtt106p in heterochromatin silencing. EMBO J. 2007 May 2; 26(9):2274-83. Epub 2007 Apr 05.
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  39. Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature. 2007 Apr 12; 446(7137):806-10. Epub 2007 Feb 21.
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  40. Han J, Zhou H, Horazdovsky B, Zhang K, Xu RM, Zhang Z. Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication. Science. 2007 Feb 2; 315(5812):653-5.
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  41. Zhou H, Madden BJ, Muddiman DC, Zhang Z. Chromatin assembly factor 1 interacts with histone H3 methylated at lysine 79 in the processes of epigenetic silencing and DNA repair. Biochemistry. 2006 Mar 7; 45(9):2852-61.
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  42. Huang S, Zhou H, Katzmann D, Hochstrasser M, Atanasova E, Zhang Z. Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13410-5. Epub 2005 Sep 12.
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  43. Zhang Z, Hayashi MK, Merkel O, Stillman B, Xu RM. Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing. EMBO J. 2002 Sep 2; 21(17):4600-11.
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  44. Zhang Z, Shibahara K, Stillman B. PCNA connects DNA replication to epigenetic inheritance in yeast. Nature. 2000 Nov 9; 408(6809):221-5.
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  45. Zhang Z, Krutchinsky A, Endicott S, Realini C, Rechsteiner M, Standing KG. Proteasome activator 11S REG or PA28: recombinant REG alpha/REG beta hetero-oligomers are heptamers. Biochemistry. 1999 Apr 27; 38(17):5651-8.
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  46. Zhang Z, Clawson A, Rechsteiner M. The proteasome activator 11 S regulator or PA28. Contribution By both alpha and beta subunits to proteasome activation. J Biol Chem. 1998 Nov 13; 273(46):30660-8.
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  47. Zhang Z, Realini C, Clawson A, Endicott S, Rechsteiner M. Proteasome activation by REG molecules lacking homolog-specific inserts. J Biol Chem. 1998 Apr 17; 273(16):9501-9.
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  48. Zhang Z, Clawson A, Realini C, Jensen CC, Knowlton JR, Hill CP, Rechsteiner M. Identification of an activation region in the proteasome activator REGalpha. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2807-11.
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  49. Knowlton JR, Johnston SC, Whitby FG, Realini C, Zhang Z, Rechsteiner M, Hill CP. Structure of the proteasome activator REGalpha (PA28alpha). Nature. 1997 Dec 11; 390(6660):639-43.
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  50. Realini C, Jensen CC, Zhang Z, Johnston SC, Knowlton JR, Hill CP, Rechsteiner M. Characterization of recombinant REGalpha, REGbeta, and REGgamma proteasome activators. J Biol Chem. 1997 Oct 10; 272(41):25483-92.
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