The Vaccine Research Group of Mayo Clinic in Rochester, Minnesota, works to improve the health of individuals across the world by pursuing challenges posed by infectious diseases and bioterrorism through clinical, laboratory and epidemiologic vaccine research. Formally founded in 1989 by Gregory A. Poland, M.D., the Vaccine Research Group is currently led by Dr. Poland and Dr. Kennedy.

The group conducts National Institutes of Health-funded research investigating the immunogenetics and systems biology of vaccine response and performs research related to novel vaccines and adjuvants in adults and children. The Vaccine Research Group uses immunological testing, including:

  • Serology, cell-mediated immunity, cell culture and cytokine assays
  • Polymerase chain reaction techniques, single nucleotide polymorphism genotyping and human leukocyte antigen typing for immunogenetic studies
  • High-throughput assays, such as next-generation sequencing, transcriptomics, epigenetics and proteomic analysis

This state-of-the-art research group and laboratory seeks to understand the genetic drivers of viral vaccine response and investigates issues surrounding novel vaccines important to public health. The Vaccine Research Group has developed the field of viral vaccine immunogenetics, the immune response network theory, and the fields of vaccinomics and adversomics.