Images

Dr. Mukhopadhyay's lab uses wild-type and knockout murine models and zebrafish models to study how proteins affect vascular permeability, angiogenesis and heart morphology.

The models allow the research team to gain a better understanding of vascular permeability by monitoring it in real time.

  • Effect of dopamine on vascular permeability

    The effect of dopamine on vascular permeability as induced by bradykinin (BK), platelet-activating factor (PAF), vascular permeability factor/vascular endothelial growth factor (VPF/VEGF).

  • Heart morphology of mice

    Heart morphology of wild-type mice (left) and smooth muscle protein 22-NRP1 knockout mice (right). The knockout mice are deficient of NRP1 in cardiomyocytes and smooth muscle cells and show enlarged right ventricles.

  • Echocardiography of mouse heart morphology

    Echocardiography of wild-type mice (left) and smooth muscle protein 22α-NRP1 knockout mice (right).

  • Head vessels of Fli:GFP zebrafish embryo

    Confocal image of the head vessels of a three-day-old Fli:GFP zebrafish embryo. Lateral view, anterior to posterior.

  • Intersegmental vessel of a zebrafish embryo

    Confocal image of intersegmental vessel of a three-day-old zebrafish embryo.

  • Microangiogram of a zebrafish embryo

    Microangiogram of a three-day-old zebrafish embryo. Image taken with Zeiss axio observer Z1.

  • Transgenic zebrafish with green heart

    Representative image of a four-day-old zebrafish embryo expressing cas9 in its heart.