The Mayo Clinic Windland Smith Rice Sudden Death Genomics Laboratory is dedicated to the discovery of novel disease-causing genes and the elucidation of genotype-phenotype relationships for i) the most common causes of autopsy negative sudden death – namely the cardiac channelopathies that include long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT), ii) sudden infant death syndrome (SIDS), and iii) the most common cause of autopsy positive sudden death in young people, especially athletes – namely hypertrophic cardiomyopathy (HCM). In addition, as Director of the Long QT Syndrome Clinic, there are active clinical translational research efforts devoted to identifying individuals at greatest risk for sudden death. These projects include autonomic nervous system studies and overnight sleep studies.