Selected Publications

  • Tebben PJ, Singh RJ, Clarke BL, Kumar R.
    Fibroblast growth factor 23, parathyroid hormone, and 1alpha,25-dihydroxyvitamin D in surgically treated primary hyperparathyroidism.
    Mayo Clin Proc. 2004 Dec;79(12):1508-13.
  • Kumar R, Lutz W, Frank E, Im HJ.
    Immediate early gene X-1 interacts with proteins that modulate apoptosis.
    Biochem Biophys Res Commun. 2004 Oct 29;323(4):1293-8.
  • Griffin MD, Xing N, Kumar R.
    Gene expression profiles in dendritic cells conditioned by
    1alpha,25-dihydroxyvitamin D3 analog.
    J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):443-8.
  • Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, van Deursen JM.
    BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.
    Nat Genet. 2004 Jul;36(7):744-9. Epub 2004 Jun 20.
  • Dong X, Craig T, Xing N, Bachman LA, Paya CV, Weih F, McKean DJ, Kumar R, Griffin MD.
    Direct transcriptional regulation of RelB by 1alpha,25-dihydroxyvitamin D3 and its analogs: physiologic and therapeutic implications for dendritic cell function.
    J Biol Chem. 2003 Dec 5;278(49):49378-85. Epub 2003 Sep 24.
  • Berndt T, Craig TA, Bowe AE, Vassiliadis J, Reczek D, Finnegan R, Jan De Beur SM, Schiavi SC, Kumar R.
    Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent.
    J Clin Invest. 2003 Sep;112(5):785-94.
  • Singh RJ, Kumar R.
    Fibroblast growth factor 23 concentrations in humoral hypercalcemia of malignancy and hyperparathyroidism.
    Mayo Clin Proc. 2003 Jul;78(7):826-9.
  • Griffin MD, Xing N, Kumar R.
    Vitamin D and its analogs as regulators of immune activation and antigen presentation.
    Annu Rev Nutr. 2003;23:117-45. Epub 2003 Mar 19. Review.
  • Gurlek A, Pittelkow MR, Kumar R.
    Modulation of growth factor/cytokine synthesis and signaling by 1alpha,25-dihydroxyvitamin D(3): implications in cell growth and differentiation.
    Endocr Rev. 2002 Dec;23(6):763-86. Review.
  • Kumar R.
    New insights into phosphate homeostasis: fibroblast growth factor 23 and frizzled-related protein-4 are phosphaturic factors derived from tumors associated with osteomalacia.
    Curr Opin Nephrol Hypertens. 2002 Sep;11(5):547-53. Review.
  • Im HJ, Craig TA, Pittelkow MR, Kumar R.
    Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression.
    Oncogene. 2002 May 23;21(23):3706-14.
  • Im HJ, Pittelkow MR, Kumar R.
    Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1.
    J Biol Chem. 2002 Apr 26;277(17):14612-21. Epub 2002 Feb 13.
  • Thompson DL, Sabbagh Y, Tenenhouse HS, Roche PC, Drezner MK, Salisbury JL, Grande JP, Poeschla EM, Kumar R.
    Ontogeny of Phex/PHEX protein expression in mouse embryo and subcellular localization in osteoblasts.
    J Bone Miner Res. 2002 Feb;17(2):311-20.
  • Craig TA, Benson LM, Venyaminov SY, Klimtchuk ES, Bajzer Z, Prendergast FG, Naylor S, Kumar R.
    The metal-binding properties of DREAM: evidence for calcium-mediated changes in DREAM structure.
    J Biol Chem. 2002 Mar 29;277(13):10955-66. Epub 2002 Jan 11.
  • Schilling D, Pittelkow MR, Kumar R.
    IEX-1, an immediate early gene, increases the rate of apoptosis in keratinocytes.
    Oncogene. 2001 Nov 29;20(55):7992-7.
  • Kumar R.
    Glucocorticoid-induced osteoporosis.
    Curr Opin Nephrol Hypertens. 2001 Sep;10(5):589-95. Review.
  • Griffin MD, Lutz W, Phan VA, Bachman LA, McKean DJ, Kumar R.
    Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo.
    Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6800-5. Epub 2001 May 22.
  • Lutz W, Kohno K, Kumar R.
    The role of heat shock protein 70 in vitamin D receptor function.
    Biochem Biophys Res Commun. 2001 Apr 20;282(5):1211-9.
  • Wu Y, Kumar R.
    Parathyroid hormone regulates transforming growth factor beta1 and beta2 synthesis in osteoblasts via divergent signaling pathways.
    J Bone Miner Res. 2000 May;15(5):879-84.
  • Lutz W, Burritt MF, Nixon DE, Kao PC, Kumar R.
    Zinc increases the activity of vitamin D-dependent promoters in osteoblasts.
    Biochem Biophys Res Commun. 2000 Apr 29;271(1):1-7.
  • Craig TA, Benson LM, Tomlinson AJ, Veenstra TD, Naylor S, Kumar R.
    Analysis of transcription complexes and effects of ligands by microelectrospray ionization mass spectrometry.
    Nat Biotechnol. 1999 Dec;17(12):1214-8.
  • Griffin MD, Torres VE, Grande JP, Kumar R.
    Vascular expression of polycystin.
    J Am Soc Nephrol. 1997 Apr;8(4):616-26.
  • Wu Y, Craig TA, Lutz WH, Kumar R.
    Identification of 1 alpha,25-dihydroxyvitamin D3 response elements in the human transforming growth factor beta 2 gene.
    Biochemistry. 1999 Mar 2;38(9):2654-60.
  • Veenstra TD, Fahnestock M, Kumar R.
    An AP-1 site in the nerve growth factor promoter is essential for 1, 25-dihydroxyvitamin D3-mediated nerve growth factor expression in osteoblasts.
    Biochemistry. 1998 Apr 28;37(17):5988-94.