Understanding the Modulation of Immune Tolerance, Dendritic Cell Function and Cellular Growth by 1α,25-Dihydroxyvitamin D

1α,25-dihydroxyvitamin D inhibits cell growth and alters apoptosis. The mechanism by which this occurs is vital in our designing cancer chemoprevention and cancer therapy protocols that include the use of 1α,25-dihydroxyvitamin D and non-calcemic analogs of 1α,25-dihydroxyvitamin D. The Kumar lab has on-going research in this area. In addition, 1α,25-dihydroxyvitamin D regulates immune function, in part by regulating, dendritic cell function. In conjunction with the laboratories of Dr. Matthew Griffin and Dr. David McKean, an effort is being made to understand how 1α,25-dihydroxyvitamin D can be used in clinical transplantation and disease.