Overview

The Protein Misfolding Lab focuses on light chain amyloidosis, a deadly disease characterized by the deposition of monoclonal immunoglobulin light chains as amyloid fibrils, potentially destroying the heart, kidneys, liver or other organs. Understanding the protein misfolding and aggregation mechanisms will help us to understand these diseases and guide us to design therapeutic strategies to overcome the amyloid phenomenon.

By exploring the role of folding kinetics, misfolding pathways and stability, it is possible to understand the mechanisms of amyloid formation in light chain amyloidosis. This can help us predict the behavior and intervene in the progression of other amyloid diseases.