Heart Publications


  • Go, R. S., E. L. Ritman, W. G. Owen: Angiogenesis in rat aortic rings stimulated by very low concentrations of serum and plasma. Angiogenesis Journal 6:25-29, 2003.
  • Langheinrich, A. C., A. Michniewicz, D. G. Sedding, G. Walker, P. E. Beighley, W. S. Rau, R. M. Bohle, E. L. Ritman: Correlation of vasa vasorum neovascularization and plaque progression in aortas of apolipoprotein E-/-/low-density lipoprotein-/- double knockout mice. Arteriosclerosis, Thrombosis and Vascular Biology J 26:347-352, 2006.
  • Langheinrich, A. C., A. Michniewicz, R. M. Bohle, E. L. Ritman: Vasa vasorum neovascularization and lesion distribution among different vascular beds in apoE-/-/LDL-/- double knockout mice. Atherosclerosis 191(1):73-81, 2007.
  • Langheinrich, A. C., A. Michniewicz, D. G. Sedding, B. Lai, S. M. Jorgensen, R. M. Bohle, E. L. Ritman: Quantitative x-ray imaging of intraplaque hemorrhage in aortas of apoE-/-/LDL-/- double knockout mice. Investigative Radiology 42(5):263-273, 2007.
  • Langheinrich, A. C., D. G. Sedding, M. Kampschulte, R. Moritz, J. Wilhelm, W. G. Haberbosch, E. L. Ritman, R. M. Bohle: 3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE-/-/LDL-/- double knockout mice. Atherosclerosis
  • Langheinrich, A. C., M. Kampschulte, C. Crößmann, R. Moritz, W. S. Rau, R. M. Bohle, E. L. Ritman: Role of CT voxel size in detection and discrimination of calcium and iron deposits in atherosclerotic human coronary artery specimens. Journal of Computed Assisted Tomography

Myocardial blood vessels

  • Rodriguez-Porcel, M., A. Lerman, E. L. Ritman, S. H. Wilson, P. J.M. Best and L. O. Lerman: Altered myocardial microvascular 3D architecture in experimental hypercholesterolemia. Circulation 102:2028-2030, 2000.
  • Zhu, X-Y., M. Rodriguez-Porcel, M. D. Bentley, A. R. Chade, V. Sica, C. Napoli, N. Caplice, E. L. Ritman, A. Lerman and L. O. Lerman: Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia. Circulation 109: 2109-2115, 2004.
  • Malyar, N. M., M. Gössl, P. E. Beighley and E. L. Ritman: Relationship between arterial diameter and perfused tissue volume in myocardial microcirculation - A micro-CT based analysis. Am J Physiol (Heart, Circ Physiol) 286:H2386-H2392, 2004.
  • Malyar, N. M., L. O. Lerman, M. Gössl, P. E. Beighley and E. L. Ritman: Relation of non-perfused myocardial volume and surface area to left ventricular performance in coronary microembolization. Circulation 110:1946-1952, 2004.
  • Toyota, E., D. C. Warltier, T. Brock, E. L. Ritman, C. Kolz, P. O'Malley, P. Rocic, M. Focardi and W. M. Chilian: Vascular endothelial growth factor is required for coronary collateral growth in the rat. Circulation 112(14):2108-2113, 2005.
  • Rodriguez-Porcel, M., X. Y. Zhu, A. R. Chade, B. Amores-Arriaga, N. M. Caplice, E. L. Ritman, A. Lerman, L. O. Lerman: Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension. Am J Physiol: Heart Circ Physiol 290:H978–H984, 2006.
  • Beighley, P. E., P. J. Thomas, S. M. Jorgensen and E. L. Ritman: 3D architecture of myocardial microcirculation in intact rat heart: A study with micro-CT. IN: Sideman S., Beyar R. (eds.): Analytical and Quantitative Cardiology. Plenum Press, New York, 1997, Chapter 14, pp 165-175.
  • Dong, Y., P. E. Beighley, D. R. Eaker, M. Zamir, E. L. Ritman: Intramyocardial capillary blood volume estimated by whole-body CT – validation by micro-CT. Proc SPIE, Medical Imaging 2008, 6916:691624-1—691624-6, 2008.
  • Schaefer, H. M., P. E. Beighley, D. R. Eaker, A. J. Vercnocke, E. L. Ritman: Micro-CT analysis of myocardial blood supply in young and adult rats. Proc SPIE Medical Imaging 7262:726225-1 – 726225-6, 2009.


  • Lerman, A. and E. L. Ritman: Evaluation of microvascular anatomy by micro-CT. Herz 24:531-533, 1999
  • Kwon, H. M., G. Sangiorgi, E. L. Ritman, C. McKenna, D. R. Holmes Jr., R. S. Schwartz and A. Lerman: Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia. Journal Clinical Investigation 101(8):1551-1556, 1998.
  • Kwon, H. M., G. Sangiorgi, E. L. Ritman, A. Lerman, C. McKenna, R. Virmani, W. D. Edwards, D. R. Holmes and R. S. Schwartz: Adventitial vasa vasorum in balloon-injured coronary arteries - visualization and quantitation by a microscopic three-dimensional computed tomography technique. Journal of the American College of Cardiology 32(7):2072-2079, 1998.
  • Herrmann, J., L. O. Lerman, M. G. Rodriguez-Porcel, D. R. Holmes, Jr., D. M. Richardson, E. L. Ritman and A. Lerman: Coronary vasa vasorum neovascularization precedes epicardial endothelial dysfunction in experimental hypercholesterolemia. Cardiovasc Res 51:762-766, 2001.
  • Herrmann, J., P. J. Best, E. L. Ritman, D. R. Holmes Jr., L. O. Lerman and A. Lerman: Chronic endothelin receptor antagonism prevents coronary vasa vasorum neovascularization in experimental hypercholesterolemia. J Am Coll Cardiol 39(9):1555-1561, 2002.
  • Wilson, S. H., J. Herrmann, L. O. Lerman, D. R. Holmes, Jr., C. Napoli, E. L. Ritman and A. Lerman: Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering. Circulation 105:415-418, 2002.
  • Goessl, M., M. Rosol, N. M. Malyar, L. A. Fitzpatrick, P. E. Beighley, M. Zamir and E. L. Ritman: Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary artery. The Anatomical Record Prt A, 272A:526-537, 2003.
  • Gössl, M., N. Malyar, M. Rosol, P. E. Beighley and E. L. Ritman: Impact of coronary vasa vasorum functional structure on coronary vessel wall perfusion distribution. Am J Physiol: Heart, Circ Physiol 285:H2019-H2026, 2003.
  • Gössl, M., M. Zamir, and E. L. Ritman: Vasa vasorum growth in the coronary arteries of newborn pigs. Anatomy and Embryology 208:351-357, 2004.
  • Gössl, M., P. E. Beighley, N. M. Malyar and E. L. Ritman: Role of vasa vasorum in transendothelial solute transport in the coronary vessel wall: A study with cryostatic micro-CT. Am J Physiology: Heart, Circ Physiol 287(5):H2346-2351 (Nov) 2004.
  • Ritman, E. L., A. Lerman: Role of vasa vasorum in arterial disease: A re-emerging factor. Current Cardiology Reviews 3(1):43-55, 2007. [Invited Review].
  • Zhu, X. Y., E. Daghini, A. R. Chade, C. Napoli, E. L. Ritman, A. Lerman, L. O. Lerman: Simvastatin prevents coronary microvascular remodeling in renovascular hypertensive pigs. Journal American Society Nephrology 18:1209-1217, 2007.
  • Gössl, M., D. Versari, D. Mannhein, E. L. Ritman, L. O. Lerman, A. Lerman: Increased spatial vasa vasorum density in proximal LAD in hypercholesterolemia – Implications for vulnerable plaque-development. Atherosclerosis 192(2):246-252, 2007.
  • Dedkov, E. I., M. T. Thomas, M. Sonka, F. Yang, T. W. Chittenden, J. M. Rhodes, M. Simons, E. L. Ritman, R. J. Tomanek: Synectin/syndecan-4 regulate coronary arteriolar growth during development. Developmental Dynamics 236:2004-2010, 2007.
  • Zhu, X-Y., M. D. Bentley, A. R. Chade, E. L. Ritman, A. Lerman, L. O. Lerman: Early changes in coronary artery wall structure detected by micro computed tomography in experimental hypercholesterolemia. Am J Physiol: Heart Circ Physiol 293(3):H1997-H2003, 2007.
  • Lund, P. E., L. C. Naessens, C. A. Seaman, D. A. Reyes and E. L. Ritman: Volume of myocardium perfused by coronary artery branches as estimated from 3D micro-CT images of rat hearts. Proc of SPIE – Medical Imaging 2000: Physiology and Function from Multidisciplinary Images 3978:314-319, 2000.
  • Gossl, M., D. Versari, L. O. Lerman, A. R. Chade, P. E. Beighley, R. Erbel, E. L. Ritman: Low vasa vasorum densities correlate with inflammation and subintimal thickening: Potential role in location-determination of atherogenesis. Atherosclerosis (Mar.) 2009. [Epub ahead of print]


  • Kwon, H. M., B. K. Hong, G. J. Jang, D. S. Kim, E. Y. Choi, I. J. Kim, C. J. McKenna, E. L. Ritman and R. S. Schwartz: Percutaneous transmyocardial revascularization induces angiogenesis: A histologic and 3-dimensional micro computed tomography study. Journal of Korean Medical Sciences 14:14:502-510, 1999.

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