About Dr. Bu

Photo of Guojun Bu, Ph.D.

Guojun Bu, Ph.D., a cell biologist and neuroscientist, is a leader in the field of research related to the low-density lipoprotein receptor (LDLR) family. He is a consultant in the Department of Neuroscience at the Mayo Clinic campus in Florida and holds the academic rank of professor of neuroscience in the College of Medicine, Mayo Clinic. Dr. Bu serves as an editor-in-chief of Molecular Neurodegeneration, an open-access journal.

Dr. Bu's scientific contributions have garnered numerous awards, including the Established Investigator Award from the American Heart Association and the Zenith Fellows award from the Alzheimer's Association.

In the early 1990s, his research identified low-density lipoprotein receptor-related protein (LRP) as the endocytic receptor for tissue-type plasminogen activator, an enzyme used clinically to dissolve blood clots during myocardial infarction and stroke. Dr. Bu also studied mechanisms underlying the biogenesis and intracellular trafficking of lipoprotein receptors. In the mid-1990s, he helped define the receptor-associated protein (RAP) as a specialized molecular chaperone and antagonist for LRP, and his laboratory has delineated the molecular mechanisms underlying interactions between RAP and LRP.

In the past 15 years, his research has been focused on dissecting the pathogenic pathways of Alzheimer's disease, specifically the roles of apolipoprotein E (apoE) and its receptors in brain lipid metabolism, synaptic functions and the metabolism of toxic amyloid-beta peptides. His research also involved analyzing the roles of LRPs in the development and progression of several cancers and identifying novel targets for therapy.

Dr. Bu's current research aims to define the roles of LRPs and apoE in the pathogenesis of Alzheimer's disease, and to increase the understanding of the Wnt signaling pathway and its role in breast cancer development and progression.

Dr. Bu received his undergraduate degree in biology from Beijing Normal University, China. He received the Ph.D. degree in biochemistry and molecular biology from Virginia Tech, Blacksburg, Va., and completed his postdoctoral training in cell biology at Washington University School of Medicine, St. Louis, Mo. He served as a professor of cell biology and neuroscience at Washington University School of Medicine until October 2010, when he moved his research laboratory to Mayo Clinic in Florida.

Dr. Bu's primary research goal is to develop better ways to diagnose and treat neurodegenerative disorders and cancer through improved understanding of the molecular and cellular pathways underlying these diseases. He believes that these basic science research activities will ultimately provide individualized, targeted therapies.