Dr. Bu and his team in the Neurobiology of Alzheimer's Disease Lab utilize genetically altered mice, including conditional knockout, knockin and transgenic mouse models, to study the functions of apoE and apoE receptors in brain lipid metabolism, signal transduction, synaptic transmission, neuronal viability and memory. Primary cultures of neurons and glial cells also are used to study the underlying cellular mechanisms. Several new mouse models have been developed in the laboratory to uncover the apoE isoform-specific effects in an age-dependent manner and to determine how apoE receptors further modulate these events.

The ultimate goals of the lab are to understand why apoE4 is a strong risk factor for Alzheimer's disease and to target this pathway for therapy to treat this devastating disease.