Noninvasive Characterization of Renal Stones

Principal Investigator
Cynthia H. McCollough, Ph.D.

Drs. McCollough, Primak, Vrtiska, and Williams have assembled strong preliminary data that demonstrate the power of dual-energy CT scanning to differentiate the chemical composition of uric acid versus calcium containing kidney stones. In this protocol, they are expanding upon this work in order to perfect and validate these techniques in vitro using appropriate phantom models. They are developing protocols to maximize the detection limits of currently available and powerful CT technology (e.g., dual-energy CT). These studies will fill an important gap in current nephrolithiasis research, allowing accurate discrimination amongst stone types and precursor lesions. The findings will greatly improve the ability to conduct noninvasive clinical research protocols as well as to accurately diagnose and monitor patients. These studies will also synergistically interact strongly with Project 2: CT and urinary correlates of renal stone precursor lesions.