Role of circadian clock genes in regulation of beta cell function, survival, regeneration and maturation

Intracellular circadian clocks (clock genes) are a highly conserved set of core genes that exert circadian control over numerous essential cellular functions such as metabolism, proliferation, survival and mitochondrial function. Dr. Matveyenko's research group is exploring molecular mechanisms by which clock genes regulate cellular function, regeneration and maturation with a focus on pancreatic beta cells. Therapeutic regulation of beta cell clock gene expression potentially presents a novel therapeutic approach to combat beta cell pathology in type 2 diabetes mellitus.