The Integrated Carbohydrate Physiology and Translation Laboratory is testing an ambulatory artificial pancreas using subcutaneous glucose sensing and insulin delivery.
The premise of an effective and safe artificial pancreas system begins with accurate continuous glucose sensing within the interstitial fluid of the subcutaneous space.
However, the artificial pancreas closed-loop system has limitations in:
- Understanding the kinetics of glucose transport between the intravascular compartment and the subcutaneous tissue where the glucose sensors are lodged
- Precision and accuracy of currently available glucose sensors
The research team of Drs. Ananda Basu and Rita Basu is involved in conducting pioneering experiments that apply innovative isotope dilution techniques and methods to determine the kinetics of glucose transport and the modulating effects of meals, activity and obesity.
Defining these parameters will close a vital gap in the understanding of the physiology of glucose transport. It also will help refine and improve closed-loop control algorithms that account for the kinetic delay by applying an arbitrary time lag in the algorithm.
In addition, the lab's research team is collaborating with Steven Koester, Ph.D., an electrical engineer at the University of Minnesota, to explore novel varactors derived from carbon that could be used as innovative glucose sensors. This collaboration addresses several of the shortcomings with current glucose sensing approaches.