Overview

Our research primarily involves human integrative physiology with a general focus on acute and chronic respiratory system adaptations or maladaptations to disease and the environment. More specifically we are involved in studies in the heart failure and chronic obstructive disease (COPD) populations on the contribution of altered cardiac function on lung mechanics, gas exchange and ventilatory control and in turn, the influence of airway obstruction and hyperinflation on cardiac function both at rest and during exercise. In addition we are interested in the contribution of locomotor muscle metaborecpetors to the ventilatory response to exercise in heart failure patients and have ongoing studies on lung fluid balance in heart failure patients. Finally, our laboratory is also involved in human adaptation to high altitude and cold inhalation.

Our laboratory is funded by grants from the National Institutes of Health, the National Science Foundation as well as industry. Techniques developed in our laboratory include a number of measures made with inert and soluble gases, including measures of airway blood flow, pulmonary capillary blood volume, pulmonary blood flow (cardiac output) and alveolar-capillary conductance. In addition we are using CT imaging to quantify airway lumen volumes, airway wall thickness, pulmonary vascular volumes. In addition, we have developed software to assess lung mechanics (work and cost of breathing) and general gas exchange.

Our laboratory collaborates with a number of colleagues at Mayo Clinic, other U.S and international investigators.