See Dr. Poeschla's publications on PubMed

HIV-1 replication

  • Llano, M., S. Delgado, M. Vanegas, and E.M. Poeschla, LEDGF/p75 prevents proteasomal degradation of HIV-1 integrase. J Biol Chem, 2004.
    279(53): p. 55570-7.
  • Llano, M., M. Vanegas, O. Fregoso, D.T. Saenz, S. Chung, M. Peretz, and E.M. Poeschla, LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral pre-integration complexes. J Virol, 2004. 78(17): p. 9524-37.
  • Ciuffi, A., M. Llano, E. Poeschla, C. Hoffmann, J. Leipzig, P. Shinn, J.R. Ecker, and F. Bushman, A role for LEDGF/p75 in targeting HIV DNA integration. Nature Medicine, 2005. 11: p. 1287-9.
  • Vanegas, M., M. Llano, S. Delgado, D. Thompson, M. Peretz, and E. Poeschla, Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering. J Cell Sci, 2005. 118(Pt 8): p. 1733-43.
  • Llano, M., D.T. Saenz, A. Meehan, P. Wongthida, M. Peretz, W.H. Walker, W. Teo, and E.M. Poeschla, An Essential Role for LEDGF/p75 in HIV Integration. Science, 2006. 314(5798): p. 461-4.
  • Llano, M., M. Vanegas, N. Hutchins, D. Thompson, S. Delgado, and E.M. Poeschla, Identification and Characterization of the Chromatin Binding Domains of the HIV-1 Integrase Interactor LEDGF/p75. Journal of Molecular Biology, 2006. 360: p. 760-73.
  • Marshall, H.M., K. Ronen, C. Berry, M. Llano, H. Sutherland, D. Saenz, W. Bickmore, E. Poeschla, and F.D. Bushman, Role of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration Targeting. PLoS ONE, 2007. 2(12): p. e1340.
  • Poeschla, E.M., Integrase, LEDGF/p75 and HIV replication. Cell Mol Life Sci, 2008. Feb 12; epub ahead of print.

Lentiviral vectors, human gene therapy

  • Poeschla, E., F. Wong-Staal, and D. Looney, Efficient transduction of nondividing cells by feline immunodeficiency virus lentiviral vectors. Nature Medicine, 1998. 4(3): p. 354-357.
  • Poeschla, E.M., Non-primate lentiviral vectors. Curr Opin Mol Ther, 2003.
    5(5): p. 529-40.
  • Loewen, N., M.P. Fautsch, W.L. Teo, C.K. Bahler, D.H. Johnson, and E.M. Poeschla, Long-term, targeted genetic modification of the aqueous humor outflow tract coupled with noninvasive imaging of gene expression in vivo. Invest Ophthalmol Vis Sci, 2004. 45(9): p. 3091-8.
  • Saenz, D.T., R. Barraza, N. Loewen, W. Teo, and E. Poeschla, Production and Use of Feline Immunodeficiency Virus (FIV)-based lentiviral vectors, in Gene Transfer: A Cold Spring Harbor Laboratory Manual, J. Rossi and T. Friedman, Editors. 2006, Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY. p. 57-74.
  • Khare, P., N. Loewen, W. Teo, R.A. Barraza, D.T. Saenz, J.D. H., and E.M. Poeschla, Durable, safe, multi-gene lentiviral vector expression in feline trabecular meshwork. Molecular Therapy, 2007. 16(1): p. 97-106.
  • Llano, M., N. Gaznick, and E.M. Poeschla, Rapid, controlled and intensive lentiviral vector-based RNAi, in HIV Protocols, second edition [in press], G. Kalpana and V. Prasad, Editors. 2007, Humana Press: Totowa, NJ.
  • Barraza RA, Poeschla EM. Human gene therapy vectors derived from feline lentiviruses. Vet Immunol Immunopathol. 2008 May 15;123(1-2):23-31.
  • Barraza RA, Rasmussen C, Loewen N, Cameron JD, Gabelt BT, Teo W, Kaufman PL, Poeschla EM. Prolonged transgene expression with lentiviral vectors in the aqueous humor outflow pathway of non-human primates. Human Gene Therapy.
    2008 Nov 26.