The Gut Microbiome Laboratory of Purna C. Kashyap, MBBS, studies the mechanisms by which gut microbes influence gastrointestinal motility in health and disease.

The human gastrointestinal (GI) tract harbors 100 trillion microbes that live in harmony with their human host and perform processes vital for health. Changes in the normal gut microflora (for example, dysbiosis) have been associated with a number of disease states with changes in GI motility, such as irritable bowel syndrome, Clostridium difficile colitis and inflammatory bowel disease; however, the functional role of gut microbes in regulating GI motility remains largely unknown.

Projects in Dr. Kashyap's laboratory aim to elucidate the complex interactions between diet, gut microbes, host genotype and GI motility. To pursue these objectives, the lab integrates data generated from multiomic platforms with in vivo and in vitro physiological measurements to identify novel bacterial taxa and microbial metabolites that affect the key regulators of GI motility. By combining experimental strategies with bioinformatics analysis, the hope is that novel microbiota-targeted therapies will be developed for treating GI motility disorders.