A Novel Cis-acting Element in a Gammaretrovirus

The lab of Dr. Ikeda has studied the epidemiology, biology and pathogenicity of a novel gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), which was initially found in prostate cancer tissues.1,2 The lab recently found a cis-acting element that enhanced expression of XMRV protein Env and is analyzing its mechanism.


  1. Sakuma T, et al. Early events in retrovirus XMRV infection of the wild-derived mouse Mus pahari. Journal of Virology. 2011;85:1205.
  2. Sakuma T, et al. No evidence of XMRV in prostate cancer cohorts in the Midwestern United States. Retrovirology. 2011;8:23.