With these projects, Dr. Farrugia's laboratory seeks to understand the cellular mechanisms that lead to the development of gastroparesis and to develop new strategies to stop and reverse these defects.
This work is supported by two large grants from the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health. The program project grant, titled Pathobiology of the Enteric System and directed by Joseph Szurszewski, Ph.D., funds the lab's work on the role of heme oxygenase-1 in diabetic gastroparesis.
The lab is also part of the Gastroparesis Clinical Research Consortium, the largest-ever effort to understand the mechanisms underlying diabetic and idiopathic gastroparesis in the U.S. The consortium is based on collaborations with multiple academic medical centers across the country.