Click here to see Dr. Ling's complete list of publications.

Recent Publications

  • Ling, K., Ma, L., and Pei, G. (1998) Differential efficacies of kappa agonists to induce homologous desensitization of human kappa opioid receptor. Neurosci. Lett. 240:25-28.
  • Ren, X.H., Zhao, J., Pu, L., Ling, K., Yin, D.L., and Pei, G. (1998) Differential neurotoxicity of etorphine-like opiates: lack of correlation with their ability to activate opiate receptors. Toxicon. 36:735-743.
  • Ling, K., Wang, P., Zhao, J., Wu, Y.L., Cheng, Z.J., Wu, G.X., Hu, W., Ma, L., and Pei, G. (1999) Five-transmembrane domains appear sufficient for a G protein-coupled receptor: Functional five-transmembrane domain chemokine receptors. Proc. Natl. Acad. Sci. U.S.A. 96:7922-7927.
  • Zhao, J., Ben, L.H., Wu, Y.L., Hu, W., Ling, K., Xin, S.M., Nie, H.L., Ma, L., and Pei, G. (1999) Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors. J. Exp. Med. 190:101-111.
  • Zhou, T.H., Ling, K., Guo, J., Zhao, H., Wu, Y.L., Jing, Q., Ma, L., and Pei, G. (2000) Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. J. Biol. Chem. 275:2513-2519.
  • Cen, B., Yu, Q., Guo, J., Wu, Y.L., Ling, K., Cheng, Z.J., Ma, L., and Pei, G. (2001) Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor. J. Neurochem. 76:1887-1894.
  • Ling, K., Doughman, R.L., Firestone, A.J., Bunce, M.W., and Anderson, R.A. (2002).Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature 420:89-93.
  • Huang, X., Shen, J., Cui, M., Shen, L., Luo, X., Ling, K., Pei, G., Jiang, H., and Chen, K. (2003) Molecular dynamics simulations on SDF-1alpha: binding with CXCR4 receptor. Biophys. J. 84:171-184.
  • Ling, K., Doughman, R.L., Iyer, V.V., Firestone, A.J., Bairstow S.F., Mosher, D.F., Schaller, M.D., and Anderson, R.A. (2003) Tyrosine phosphorylation of type Ig phosphatidylinositol phosphate kinase by Src regulates an integrin/talin switch. J. Cell. Biol. 163:1339-1349.
  • Bairstow, S.F. Ling, K. and Anderson, R.A. (2005) Type Ig phosphatidylinositol phosphate kinase associates with regulates the SHP-1 tyrosine phosphatase. J. Biol. Chem. 280: 23884-23891
  • Bairstow, S.F., Ling, K., Su, X.J., Firestone, A.J., Carbonara, C. and Anderson, R.A. (2006) Type Ig661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis. J. Biol. Chem. 281: 20632-20642.
  • Ling, K., Schill, N.J., Wagoner, M., Sun Y. and Anderson, R.A. (2006) Movin’ on up: the role of PI4,5P2 in cell migration. Trends in Cell Biology. 16: 276-284.
  • Ling, K., Bairstow, S.F., Carbonara, C., Turbin, D.A., Huntsman, D.G., and Anderson, R.A. (2007) Type Ig PIP kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with m1B adaptin. J. Cell Biol. 176: 343-353.
  • Heck, J.N., Mellman, D.L., Ling, K., Sun, Y., Wagoner, M.P., Schill, N.J., and Anderson, R.A. (2007) A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family. Crit. Rev. Biochem. Mol. Biol. 42:15-39.
  • El Sayegh, T.Y., Arora, P.D., Ling, K., Laschinger, C., Janmey, P.A., Anderson, R.A., and McCulloch, C.A. (2007) Phosphatidylinositol-4,5 bisphosphate produced by PIP5KIgamma regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions. Mol. Biol. Cell. 18:3026-3038.
  • Sun, Y., Ling, K., Wagoner, M.P., and Anderson, R.A. (2007) Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration. J. Cell Biol. 178:297-308.