Imaging of Stem Cell Differentiation
While regarded as successful therapies, many questions remain whether stem cells actually differentiate in the living subject, and what are the mechanisms behind it. As of now we have not been able to monitor stem cell differentiation in vivo due to the lack of appropriate imaging modalities. That has changed recently. In this project we pose to develop imaging strategies that will allow us to visualize when stem cells differentiate into different cell lineages.
Our overall goal is to use these monitoring strategies to assess the efficacy of cardiac gene and cell therapy and use what we learned from our biological studies to design improved therapeutic strategies for cardiovascular diseases.