Cell Therapy in PKD
Polycystic Kidney Disease (PKD) is the most common inherited renal cystic disease and is characterized by renovascular and renal tubular derangements. Currently, there is no effective therapy for this disease. Recently, cell-based therapies have appeared as potential therapeutic strategies for many renal diseases.
The overall aim of this project is to assess the potential of cell-based therapy for restoring renal function and structure in PKD. The potential effect of different progenitor cells in PKD on renal structure and function will be investigated using state-of-the-art imaging modalities (e.g., micro-CT, micro-ultrasound, optical molecular imaging).
Our laboratory studies will permit a better understanding of the pathophysiology of PKD and the potential of cell therapies to treat this disease.