The Cardiovascular Genetics Laboratory of Timothy M. Olson, M.D., at Mayo Clinic studies the important role that hereditary factors play in the development and progression of cardiovascular diseases.
In particular, the objective of our research program in the Cardiovascular Genetics Lab is to discover genetic variants that cause or confer susceptibility to heart and blood vessel disorders in otherwise healthy children and young adults.
Family-based experimental strategies include genetic linkage analysis to map the genomic location of novel disease genes, whole-exome and -genome sequencing, and hypothesis-based mutation scanning of candidate genes.
Research in the Cardiovascular Genetics Lab focuses on three heritable conditions:
Significance to patient care
The long-term objective of our research is to decipher the underlying molecular mechanisms of idiopathic cardiovascular disorders and apply this knowledge to new diagnostic and therapeutic solutions for patients and their families.