Illustration of plaque build-up in an artery.

The Cardiovascular Disease and Aging Laboratory of Jordan D. Miller, Ph.D., at Mayo Clinic focuses on several areas of research, including:

  • Understanding the mechanisms that contribute to aortic valve and atherosclerotic plaque calcification
  • Identification of reciprocal regulators of skeletal and cardiovascular calcification
  • Understanding the mechanisms that contribute to vasomotor dysfunction in health and disease

Through the use of molecular screening on human tissue, novel strains of genetically modified mice, and in vitro and cell culture methods, the Cardiovascular Disease and Aging Lab aims to develop novel therapies for the treatment of cardiovascular disease and age-related disease.