Inhibition of Fibroblast Growth Factor Receptor 3 Induces Differentiation and Apoptosis in t(4;14) Myeloma.

The O'Brien Urology Research Center investigates what we believe are critical unanswered questions in nephrolithiasis research. These questions are addressed through an integrated approach that includes translational imaging research to develop a noninvasive, in vivo diagnostic test to characterize kidney mineralization; basic science investigation of the molecular mechanisms oxalate transport; definition of the key urinary factors (electrolyte and proteomic) that drive formation of nascent renal stones; and epidemiologic and biochemical investigation of the relationship between nephrolithiasis and CKD in order to allow early identification of those at risk.

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