Muscle Mechanics Projects

Magnetic resonance elastography of meningiomas

The specific aim of this project is to use high-resolution magnetic resonance elastography acquisition, including improved algorithms for processing magnetic resonance elastography data, to characterize meningioma stiffness.

Studies at Mayo Clinic and elsewhere have demonstrated that magnetic resonance elastography is a reliable method for diagnosing hepatic fibrosis and offers a safer, more comfortable, less expensive and potentially more accurate alternative to liver biopsy for many patients.

Recently, magnetic resonance elastography has shown promise for diffuse brain diseases. The investigators have determined that 3-D magnetic resonance elastography of the brain can be performed reproducibly and demonstrates significantly reduced brain tissue stiffness in people with Alzheimer's disease.

Magnetic resonance elastography on myofascial taut bands

The goal of this project is to further test the hypothesis that magnetic resonance elastography stiffness measurements of myofascial taut bands are repeatable and that magnetic resonance elastography is sensitive to changes resulting from manual therapies.

A preliminary study by the investigators has, for the first time, imaged myofascial taut bands based on their stiffness values. This was accomplished using magnetic resonance elastography. If the magnetic resonance elastography technique is repeatable and sensitive, it can be used to assess the efficacy of manual therapies in future studies.