Integrated Approaches to Close the Loop in Type 1 Diabetes: Role of Diurnal Variation in Insulin Action

Circadian and intraindividual variations in post-meal glucose fluxes, which influence post-meal glucose excursion and variability, have not been studied with state-of-the-art technology in type 1 diabetes mellitus (T1DM). This remains a key limitation in the development of continuous, closed-loop, subcutaneous insulin-delivery systems.

An improved understanding of these factors will help optimize mealtime insulin delivery and limit post-meal hyperglycemia in T1DM. Our study design has addressed these critical issues by examining subjects with T1DM and normal gastric emptying on three consecutive days while controlling for meal composition and insulin dosing.

We will periodically provide summary results of this study after its completion in April 2012.