Spheroid Reservoir Bioartificial Liver
The Artificial Liver and Liver Transplantation Laboratory of Scott L. Nyberg, M.D., Ph.D., has recently developed a novel device, the Spheroid Reservoir Bioartificial Liver (SRBAL), which is being evaluated in a preclinical model of liver failure with the ultimate goal of bedside treatment of patients in liver failure.
Schematic of the automated spheroid reservoir
Schematic of the automated spheroid reservoir, which was developed by the Mayo Clinic Division of Engineering.
Spheroid reservoir loaded with 200 grams of porcine hepatocyte spheroids
Schematic of the extracorporeal circuit of the Spheroid Reservoir Bioartificial Liver
Prototype of the Spheroid Reservoir Bioartificial Liver
Histology of acute liver injury secondary to drug overdose
If untreated, this histology is associated with the development of fulminant hepatic failure, coma and brain death. Primary treatment of fulminant liver failure consists of liver transplantation. The SRBAL is a potential bridge to liver transplantation, or it may provide temporary support until spontaneous recovery of the native liver.