The Mayo Clinic Institutional Review Board (IRB) ensures that the rights and well-being of potential research subjects are adequately protected.

The Institutional Review Board is charged with reviewing all studies involving human subjects for compliance with institutional policies and with state, local and federal laws. The IRB also ensures that all studies comply with the ethical principles contained in the Belmont Report, such as respect for people, beneficence and justice.

The Mayo Clinic IRB is made up of four committees comprising at least five members, including Mayo Clinic scientists and nonscientists, and at least one member who is not affiliated with the institution.