Sushant M. Ranadive, Ph.D., studies many aspects of human physiology with a focus on aging, sex differences, cardiovascular function and blood pressure regulation. He is currently studying the mechanisms related to the higher prevalence of hypertension in postmenopausal women as compared with age-matched men. Dr. Ranadive has developed a keen interest in addressing the effects of regular physical activity in this population, given the paucity of knowledge in this area.
- Vascular function and blood flow regulation. Vasodilatory response in humans to a variety of stimuli has been shown to precede major cardiovascular events. Vascular function decreases or deteriorates with inflammation and oxidative stress or in the presence of a disease condition. Dr. Ranadive studies the causes of, mechanisms involved and potential therapeutic measures to improve function of the arteries.
- Preeclampsia. Dr. Ranadive studies the prevalence and development of hypertension in women with a history of preeclampsia from the perspective of vascular dysfunction and autonomic control.
- Hypertension. Dr. Ranadive studies the mechanisms involved with increased development of hypertension in postmenopausal women. He is looking at the relationship between β-adrenergic receptor function, loss of estrogen and increased blood pressure.
Significance to patient care
Dr. Ranadive's research will provide better understanding of the mechanisms involved in higher rates of hypertension in postmenopausal women. This knowledge will help improve pharmacological and non pharmacological interventions to improve blood pressure in women.
- Recipient, Caroline tum Suden/Frances Hellebrandt Professional Opportunity Award, 2015