The research interest of Amy E. Krambeck, M.D., is in advanced endourologic treatment of urinary stones (urolithiasis) and enlarged prostate glands (benign prostatic hyperplasia or BPH).

Current ongoing projects in the area of urolithiasis research include a collaborative effort among researchers in urology, radiology, pathology and nephrology evaluating the pathogenesis of stone disease. By evaluating different urologic, endoscopic, radiologic and pathologic findings, the team's goal is to identify underlying physiological events related to stone formation.

Dr. Krambeck has evaluated and continues to explore the role of surgical intervention for benign prostatic hyperplasia in men with poorly contractile or acontractile bladders.

Focus areas

  • Percutaneous nephrolithotomy. Dr. Krambeck is participating in a project to evaluate for the presence of stone precursor lesions (Randall's plaques and Bellini duct plugs) at the time of percutaneous stone removal. This study involves a comprehensive evaluation of the patient's urine metabolic profile, digital imaging and mapping of the renal papillae, and a papillary biopsy at the time of surgical intervention.
  • Urolithiasis during pregnancy. Dr. Krambeck has a special interest in the treatment of urolithiasis during pregnancy, focusing on surgical removal of symptomatic stones and metabolic assessment of risk factors for stone formation during pregnancy.
  • Benign prostatic hyperplasia. Dr. Krambeck is currently evaluating the role of holmium laser enucleation of the prostate (HoLEP) for the treatment of urinary retention associated with benign prostatic hyperplasia and a poorly contractile bladder.
  • Ureteroscopy. Dr. Krambeck is part of a multi-institutional study of the benefits and long-term effects of laser dusting vs. fragmentation and basket extraction of stones at the time of surgical intervention.

Significance to patient care

Dr. Krambeck's research addresses many unmet needs in the areas of urolithiasis and benign prostatic hyperplasia. Through her multidisciplinary work, she is advancing research in the area of low-dose imaging for stone disease as well as furthering knowledge into the pathogenesis of stone disease.

By expanding her research into treatment of urolithiasis during pregnancy and surgical intervention for benign prostatic hyperplasia in patients with acontractile bladders, Dr. Krambeck is focusing on meeting the needs of special patient populations by improving the safety and quality of patient care.

Professional highlights

  • Member, Guidelines for the Surgical Treatment of Stone Disease, American Urological Association, 2013-present
  • Recipient, American Urological Association Research Forum Award, 2013
  • Recipient, Mayo Brothers Distinguished Fellowship Award, 2007


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