Location

Rochester, Minnesota

Contact

Ekker.Stephen@mayo.edu

Summary

Dr. Stephen C. Ekker's zebrafish genetics laboratory is focused on one major next step in the post-genomics era: Assignment of genes and gene sets critical in vertebrate patterning and organogenesis.

Dr. Ekker's lab has developed two approaches for the identification of new genes and genetic networks: vertebrate transposons and morpholino antisense oligonucleotides for molecular genetic manipulation of the zebrafish. We are undertaking a morpholino-based screen of the major subset of the genome encoded by co-translationally translocated proteins to identify novel key players critical for clinically relevant processes such as blood vessel, sensory organ and kidney development. We have also developed gene-breaking transposons as insertional mutagens, a tool that opens the door to an array of important questions such as the genetic basis of nicotine sensitization, a critical process that underlies nicotine addiction. These two reagents, morpholinos and mutagenic transposons, are powerful tools for use in true functional genomics applications in the model vertebrate, the zebrafish.

For more information about my research, please visit:

Recent Publications

See my publications

Professional Details

Primary Appointment

  1. Biochemistry and Molecular Biology

Academic Rank

  1. Professor of Biochemistry/Molecular Biology

Education

  1. Post-doctoral Fellowship - Biochemical Properties and Biological Activities of the hedgehog Gene Family, Philip A. Beachy, advisor Johns Hopkins School of Medicine and Howard Hughes Medical Institute
  2. Post-doctoral Fellowship - Randall T. Moon, collaborative advisor University of Washington and Howard Hughes Medical Institute
  3. Doctor of Philosophy - Molecular Biology and Genetics The Johns Hopkins University
  4. Research Student - Restriction Mapping the Genome of the Archaebacterium Sulfolobus solfataricus; C.R. Woese, advisor University of Illinois
  5. BS - Electrical Engineering University of Illinois at Urbana-Champaign
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BIO-00096027

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