Research interests include: 1.) clinical trials of novel therapies for patients with primary and metastatic brain tumors; 2.) correlative studies to determine the clinical significance of histologic and genetic variables in brain tumor tissue; 3.) pharmacokinetic interactions among antineoplastic and anticonvulsant medications; 4.) neurobehavioral consequences of brain tumors and their treatment; and, 5.) methodologic issues in designing clinical trials for brain tumor patients.