Rochester, Minnesota


Clinical Studies and Translational Research in the Area of Neurofibromatosis

Examples of Research Projects

Completed Protocols:

PI: A pilot, phase II, open-label clinical trial of pirfenidone (an antifibrotic agent) in adult patients with Neurofibromatosis type I and plexiform and paraspinal neurofibromas (PI). The study was coordinated through the Mayo Clinic Cancer Center.

Co-PI: "Phase I Clinical trial of Pirfenidone in Childen and Adolescents with plexifom neurofibromas." Study was a part of multi-center clinical trial, coordinated by NCI.

Current Protocols:

Co-PI: "Phase II Clinical Trial of Pirfenidone in Children, Adolescents, and Young Adults with Neurofibtromatosis Type I and Progressive Plexiform Neurofibromas," coordinated by NCI, in collaboration with Childrens National Medical Center (PI Dr. Roger Packer).

Protocols in Development:

PI: "A Phase-2 Study of AZD2171 in Adult Patients with Neurofibromatosis Type I and Extensive Plexiform and Paraspinal Neurofibromas," coordinated by Cancer Therapy Evaluation Program (CTEP) and sponsored by AstraZeneca Pharmaceuticals; multicenter protocol with Mayo Clinic lead.

My research also involves several collaborative basic research studies in the field of neurofibromatosis, in conjunction with Mayo's Neuro-Oncology program, Radiology Department, and Neurosurgery Department.

My research interests include overgrowth syndromes, as well as various genetic syndromes and metabolic disorders.

Recent Publications

See my publications

Professional Details

Primary Appointment

  1. Medical Genetics

Joint Appointment

  1. Pediatric and Adolescent Medicine

Administrative Appointment

  1. Medical Genetics

Academic Rank

  1. Professor of Medical Genetics
  2. Professor of Pediatrics


  1. Clinician Investigator Fellow Mayo Clinic in Rochester
  2. Fellow Department of Medical Genetics
  3. Resident Department of Pediatric and Adolescent Medicine
  4. Visiting Clinician Department of Endocrinology, Royal Hospital for Sick Children
  5. Resident Children's Hospital, University of Sarajevo
  6. MMedSc - Basic Research. Thesis: ""Diagnostic and prognostic value of limited joint mobility and skin changes in juvenile diabetics"" University of Sarajevo
  7. Research Fellowship Institute of Hygiene and Protection of Human Environment, University of Sarajevo
  8. MD University of Sarajevo

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