Since 1990, the National Center for Medical Rehabilitation and Research has funded a post-doctoral Rehabilitation Research Training Program that funds five Fellows each year. The program offers five tracks: Biomechanics, Biostatistics/Epidemiology/ Health Services Research, Multiple Sclerosis, Acquired Brain Injury, and Pain. These tracks have been chosen to optimize the combination of the resources of the Mayo Clinic with important areas of rehabilitation-related research. Each track is tailored to the specific needs of a trainee, but all will begin with the trainees working for a limited time with their mentors on ongoing research projects relevant to their interests. Trainees are then expected to: (1) rapidly begin their own, self-initiated projects; (2) become capable of sustained individual research; and (3) submit NIH quality grant applications by the end of their training period.