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  1. Rochester, MN. (4)

4 studies in Department of Ophthalmology

  1. Quality of Life in Childhood Strabismus
    Rochester, Minn. View Summary

    Quality of Life in Childhood Strabismus

    Location:

    Rochester, Minn.

    Trial status:

    Open for Enrollment

    Why is this study being done?

    A brief questionnaire for the child and one for the parent explores the difficulties in dealing with Intermittent Exotropia, an out turning eye.  The information will be helpful for assessing the full implact of this condition on children and their parents.

    IRB Number:

    06-005705

    Who can I contact for additional information about this study?

    Jan Sease, coordinator:  507-538-8119 or sease.jan@mayo.edu

    Sarah Hatt, orthoptist: 507-284-1913 or hatt.sarah@mayo.edu
  2. Effect of Corneal Preservation Time on Long-Term Graft Success
    Rochester, Minn. View Summary

    Effect of Corneal Preservation Time on Long-Term Graft Success

    Location:

    Rochester, Minn.

    Trial status:

    Open for Enrollment

    Why is this study being done?

    When the donor cornea is removed from the person who died, it is prepared for transplantation by an eye bank. The donor cornea is placed into a liquid that helps preserve the cornea until it is transplanted. The Food and Drug Administration (FDA) has approved storage of the cornea in this liquid for up to 14 days before the transplant. The purpose of this study is to see if the length of time the donor cornea is kept in the preservation liquid before the transplant affects the likelihood of the transplant being successful. We will follow participants for 3 years after transplant to see if there are any differences in transplant success or in the number of transplanted endothelial cells (the layer of cells that line the undersurface of the cornea) on the corneas that were preserved for 7 days or less compared to those preserved between 8 and 14 days. We have no reason to believe that there is any greater risk for transplant failure with either preservation time group.

    NCT ID:

    NCT01537393

    Who can I contact for additional information about this study?

    Rochester: Diane Vogen 507-538-8119
                        


  3. A Multicenter, Double-masked, Placebo-controlled, Efficacy and Safety Study of an Insulin-like Growth Factor-1 Receptor (IGF-1R) Antagonist Antibody (Fully Human), in Patients With Active Thyroid Eye Disease
    Rochester, Minn. View Summary

    A Multicenter, Double-masked, Placebo-controlled, Efficacy and Safety Study of an Insulin-like Growth Factor-1 Receptor (IGF-1R) Antagonist Antibody (Fully Human), in Patients With Active Thyroid Eye Disease

    Location:

    Rochester, Minn.

    Trial status:

    Open for Enrollment

    Why is this study being done?

    The purpose of this study is to evaluate the safety, tolerability and effectiveness of a fully human antibody compared to placebo in the treatment of patients with active thyroid eye disease.

    NCT ID:

    NCT01868997

    IRB Number:

    13-007171

    Who can I contact for additional information about this study?

  4. Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance
    Rochester, Minn. View Summary

    Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance

    Location:

    Rochester, Minn.

    Trial status:

    Open for Enrollment

    Why is this study being done?

    Glaucoma is a major cause of blindness. The inability to predict a patient's IOP response to medications is a critical barrier for the clinician to consistently provide highly effective IOP-based treatments. Current trial-and error approaches to glaucoma management are inefficient and have not addressed this barrier as there are no predictive factors for drug response. Our long-term goal is to improve outcomes by identifying biomarkers and environmental factors that profile a patient at risk for glaucoma by age-of-onset, rate of disease progression, "poor response" to treatment, and large IOP fluctuation. Our purpose of this research project is to address this critical barrier by focusing on physiological factors that predict IOP response to drugs.

    NCT ID:

    NCT01677507

    Who can I contact for additional information about this study?

    Rochester: Arthur Sit, MD 507-284-2787
                        Nitika Arora, MBBS 507-284-2787