Disease-Based Research Focus

BMB Faculty are focused on understanding the basic mechanisms of disease research in the following areas:

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Cancer

Daniel D. Billadeau, Ph.D.

Daniel D. Billadeau, Ph.D.
Associate Professor of Immunology

Proteins and molecular pathways of pancreatic cancer


Fergus Couch, Ph.D.

Fergus Couch, Ph.D.
Professor, Laboratory Medicine and Pathology

Breast, ovarian, and pancreatic cancer with a specific focus on familial/inherited forms of these diseases


Stephen Ekker, Ph.D.

Stephen Ekker, Ph.D.
Professor, Biochemistry and Molecular Biology

Identification of genes and translocated proteins to understand cancer development


Robert B. Jenkins, Ph.D.

Robert B. Jenkins, Ph.D.
Professor, Laboratory Medicine and Pathology

Genetic aspects of human brain tumors, and prostate cancer


David Katzmann, Ph.D.

David Katzmann, Ph.D.
Assistant Professor, Biochemistry and Molecular Biology

Protein sorting and receptor downregulation


Edward Leof, Ph.D.

Edward Leof, Ph.D.
Professor, Biochemistry and Molecular Biology

Transforming growth factor β (TGF-β)


Kun Ling, Ph.D.

Kun Ling, Ph.D.
Assistant Professor, Biochemistry and Molecular Biology

Cell adhesion and migration


Jim Maher, Ph.D.

Jim Maher, Ph.D.
Professor, Biochemistry and Molecular Biology

Nucleic acid structure and recognition


Mark A. McNiven, Ph.D.

Mark A. McNiven, Ph.D.
Professor, Biochemistry and Molecular Biology

Cytoskeletal-membrane dynamics


Georges Mer, Ph.D.

Georges Mer, Ph.D.
Associate Professor, Biochemistry and Molecular Biology

Structural biology with relevance to cancer, neurological diseases and epigenetics


Debabrata Mukhopadhyay, Ph.D.

Debabrata Mukhopadhyay, Ph.D.
Professor, Biochemistry and Molecular Biology

Tumor angiogenesis and vascular biology


Larry Pease, Ph.D.

Larry Pease, Ph.D.
Professor, Biochemistry, Molecular Biology and Immunology

Cancer immunology and immunotherapy


Jeffrey Salisbury, Ph.D.

Jeffrey Salisbury, Ph.D.
Professor, Biochemistry and Molecular Biology

Role of the protein centrin in cancer


Thomas Spelsberg, Ph.D.

Thomas Spelsberg, Ph.D.
Professor, Biochemistry and Molecular Biology

Breast cancer


Donald Tindall, Ph.D.

Donald Tindall, Ph.D.
Professor, Biochemistry, Molecular Biology and Urology

Androgens and prostate cancer


Raul Urrutia, M.D.

Raul Urrutia, Ph.D.
Professor, Biophysics and Medicine
Assistant Professor, Biochemistry and Molecular Biology

Molecular mechanisms of pancreatic morphogenesis and cancer


Jan van Deursen, Ph.D.

Jan van Deursen, Ph.D.
Professor, Biochemistry, Molecular Biology and Pediatrics

Transcriptional coactivators in normal and neoplastic growth


Charles Y. Young, Ph.D.

Charles Y. Young, Ph.D.
Professor, Biochemistry, Molecular Biology and Urology

Prostate Cancer


Zhiguo Zhang, Ph.D.

Zhiguo Zhang, Ph.D.
Associate Professor, Biochemistry and Molecular Biology

Epigenetic silencing and epigenetic cause of cancer


 

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Cardiovascular disease/angiogenesis

H. R. Bergen, Ph.D.

H. R. Bergen, Ph.D.
Assistant Professor, Biochemistry and Molecular Biology

BNP/ANP isoforms in treatment of chronic heart failure


Frank V. Brozovich, M.D., Ph.D.

Frank V. Brozovich, M.D., Ph.D.
Professor, Medicine and Physiology

Cardiovascular contractility and signaling


Thomas P. Burghardt, Ph.D.

Thomas P. Burghardt, Ph.D.
Professor, Biochemistry and Molecular Biology

Mutations in beta-cardiac myosin


Stephen Ekker, Ph.D.

Stephen Ekker, Ph.D.
Professor, Biochemistry and Molecular Biology

Zebrafish genetics: assignment of genes and gene sets critical in vertebrate patterning and organogenesis


Edward Leof, Ph.D.

Edward Leof, Ph.D.
Professor, Biochemistry, Molecular Biology and Medicine

Transforming growth factor-ß and its downstream pathways that contribute to cellular processes in cancer, fibrotic disorders, immune modulation, and wound healing


Kun Ling, Ph.D.

Kun Ling, Ph.D.
Assistant Professor, Biochemistry and Molecular Biology

Cell adhesion and migration


Daniel J. McCormick, Ph.D.

Daniel J. McCormick, Ph.D.
Professor, Biochemistry and Molecular Biology

BNP/ANP isoforms in treatment of chronic heart failure


Debabrata Mukhopadhyay, Ph.D.

Debabrata Mukhopadhyay, Ph.D.
Professor, Biochemistry and Molecular Biology

Tumor angiogenesis and vascular biology


Robert Simari, M.D.

Robert Simari, M.D.
Professor of Medicine

To investigate and treat cardiovascular disease through modulation of gene expression


Xiaolei Xu, Ph.D.

Xiaolei Xu, Ph.D.
Assistant Professor, Biochemistry, Molecular Biology and Medicine

Zebrafish genetics


 

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Tissue degenerative diseases

Peter Harris, Ph.D.

Peter Harris, Ph.D.
Professor, Biochemistry, Molecular Biology and Medicine

Polycystic Kidney Disease


Jinghua Hu, Ph.D.

Jinghua Hu, Ph.D.
Assistant Professor, Biochemistry, Molecular Biology and Medicine

Cilia biogenesis and function


Grazia Isaya, Ph.D.

Grazia Isaya, Ph.D.
Professor, Biochemistry, Molecular Biology and Pediatrics

Mitochondrial genetics


Nicholas F. LaRusso, M.D.

Nicholas F. LaRusso, M.D.
Professor, Biochemistry, Molecular Biology and Medicine

Cholangiocytes


Ed Leof, Ph.D.

Ed Leof, Ph.D.
Professor, Biochemistry, Molecular Biology and Medicine

Transforming growth factor β and its role in the cell cycle and cancer


Merry Jo Oursler, Ph.D.

Merry Jo Oursler, Ph.D.
Professor of Medicine
Associate Professor, Biochemistry and Molecular Biology

Cell biology of bone


Joseph F. Poduslo, Ph.D.

Joseph F. Poduslo, Ph.D.
Professor, Biochemistry, Molecular Biology and Neurology

Molecular neurobiology


Marina Ramirez-Alvarado, Ph.D.

Marina Ramirez-Alvarado, Ph.D.
Assistant Professor, Biochemistry and Molecular Biology

Protein misfolding


Thomas Spelsberg, Ph.D.

Thomas Spelsberg, Ph.D.
Professor, Biochemistry and Molecular Biology

Molecular analysis of human diseases


Jennifer Westendorf, Ph.D.

Jennifer Westendorf, Ph.D.
Associate Professor, Biochemistry, Molecular Biology and Orthopedics

Osteoblast biology and transcriptional regulation


 

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Aging

Cynthia McMurray, Ph.D.

Cynthia McMurray, Ph.D.
Professor, Biochemistry, Molecular Biology and Pharmacology

DNA instability in human disease


Merry Jo Oursler, Ph.D.

Merry Jo Oursler, Ph.D.
Professor of Medicine
Associate Professor, Biochemistry and Molecular Biology

Cell biology of bone


Jan van Deursen, Ph.D.

Jan van Deursen, Ph.D.
Professor, Biochemistry, Molecular Biology and Pediatrics

Molecular basis of human cancer and cellular senescence


 

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Bio/nano technologies

Zelko Bajzer, Ph.D.

Zelko Bajzer, Ph.D.
Professor of Biophysics
Assistant Professor, Biochemistry and Molecular Biology

Biomathematics Resource


H. Robert Bergen, III, Ph.D.

H. Robert Bergen, III, Ph.D.
Assistant Professor, Biochemistry and Molecular Biology

Proteomics research and mass spectrometry


Stephen Ekker, Ph.D.

Stephen Ekker, Ph.D.
Professor, Biochemistry and Molecular Biology

Zebrafish Core Facility


Mark Federspiel, Ph.D.

Mark Federspiel, Ph.D.
Associate Professor, Biochemistry and Molecular Biology

Gene and Virus Therapy Program


Slobodan Macura, Ph.D.

Slobodan Macura, Ph.D.
Professor, Biochemistry and Molecular Biology

Analytical NMR Facility


Daniel McCormick, Ph.D.

Daniel McCormick, Ph.D.
Professor, Biochemistry and Molecular Biology

Proteomics and Peptide Synthesis Core


Georges Mer, Ph.D.

Georges Mer, Ph.D.
Associate Professor, Biochemistry and Molecular Biology

NMR spectroscopy and x-ray crystallography of protein complexes


Jan van Deursen, Ph.D.

Jan van Deursen, Ph.D.
Professor, Biochemistry, Molecular Biology and Pediatrics

Transgenic and Gene Targeted Mouse Shared Resource


Eric Wieben, Ph.D.

Eric Wieben, Ph.D.
Professor, Biochemistry and Molecular Biology