The Microscopy and Cell Analysis Core is part of the Mayo Clinic Cancer Center, which is a National Cancer Institute-designated comprehensive cancer center.

The core makes high-end optical and electron microscopic as well as state-of-the-art flow analysis and cell sorting capabilities available to investigators. Services include preparation methods, availability of turnkey instrumentation for high-resolution electron and optical microscopy, and computer-aided averaging and reconstruction. The specialized services provide access to researchers in a cost-effective manner.

Recently, technical developments have provided the ability to study biological processes in ways that were not previously attainable, such as at subnanometer resolution and in 3-D images. This includes the study of tagged proteins that can be visualized by both fluorescence and electron microscopy using correlative light and ultrastructure studies of the same cell.