Effect of Vitamin D Supplementation on Endothelial Function in Obese Adolescents
Trial status: Open for Enrollment
Why is this study being done?
Vitamin D deficiency has been linked to endothelial dysfunction in adults. Obese adolescents have a high prevalence of Vitamin D deficiency as well as evidence of endothelial dysfunction. Our hypothesis is that supplementation of Vitamin D deficient adolescents with Vitamin D would lead to improvement in endothelial dysfunction.
Who is eligible to participate?
1. Age 12-18 years
2. BMI >95% for age and gender
3. 25 (OH) D levels less than 30 ng/ml
1. 25 (OH) D levels >30 ng/mL
2. Serum calcium >10.4 mg/dL
3. Serum phosphorus > 4.7 mg/dl
4. Pregnancy or nursing
5. Current cancer
6. Patients on vitamin D3 supplementation exceeding 400 IU/day
7. Hypertension defined as Blood Pressure over the 95th percentile for age, gender and height
8. Dietary calcium intake exceeding 1500 mg/day,
9. Hepatic or renal disorders
10. Type 1 or type 2 diabetes mellitus
11. Subjects receiving insulin, metformin, or oral hypoglycemic medications
12. Subjects with malabsorption disorders (celiac disease, cystic fibrosis,inflammatory bowel disease)