Effect of Vitamin D Supplementation on Endothelial Function in Obese Adolescents


Rochester, Minn.

Trial status:
Open for Enrollment
Why is this study being done?

Vitamin D deficiency has been linked to endothelial dysfunction in adults. Obese adolescents have a high prevalence of Vitamin D deficiency as well as evidence of endothelial dysfunction. Our hypothesis is that supplementation of Vitamin D deficient adolescents with Vitamin D would lead to improvement in endothelial dysfunction.

Who is eligible to participate?

Inclusion Criteria: 1. Age 12-18 years 2. BMI >95% for age and gender 3. 25 (OH) D levels less than 30 ng/ml Exclusion Criteria: 1. 25 (OH) D levels >30 ng/mL 2. Serum calcium >10.4 mg/dL 3. Serum phosphorus > 4.7 mg/dl 4. Pregnancy or nursing 5. Current cancer 6. Patients on vitamin D3 supplementation exceeding 400 IU/day 7. Hypertension defined as Blood Pressure over the 95th percentile for age, gender and height 8. Dietary calcium intake exceeding 1500 mg/day, 9. Hepatic or renal disorders 10. Type 1 or type 2 diabetes mellitus 11. Subjects receiving insulin, metformin, or oral hypoglycemic medications 12. Subjects with malabsorption disorders (celiac disease, cystic fibrosis,inflammatory bowel disease)

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