Exploring Possible Mechanisms that Might Explain Potential Vasodilator and Sensory Effects of TJ-68

Overview

  • Study type

    Interventional
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 16-008406
    Sponsor Protocol Number: 16-008406

About this study

We will determine if a) glycyrrhetic acid (GA, a key component of TJ-68) evokes vasodilation, and b) if glycyrrhetic acid alters the TRP mediated sensory response to local heating. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion of Women and Minorities.

The proposed studies will include healthy young (18-40) men and women of all races and ethnic backgrounds recruited from Rochester, MN and surrounding communities.  This is a non-therapeutic protocol.  We expect that 50% of the subjects will be women.  We will make every effort to recruit a diverse group of subjects, but there are no race- or ethnic-specific questions in this protocol, and we therefore expect that the non-Caucasian population participating in these studies will be ~19.3%, similar to the non-Caucasian population of Olmsted County.

Inclusion of Children.

Children between the ages 18-21 will be studied.  We believe these individuals have physiologically mature blood pressure regulating systems.  Additionally, children in this age group can give informed consent for invasive procedures.  We will exclude children less than 18 years of age because they are unable to give consent, and because these studies are invasive and non-therapeutic.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Michael Joyner, M.D.

Open for enrollment

Contact information:

Shelly Roberts R.N.

(507)255-2807

roberts.shelly@mayo.edu

.
CLS-20306569

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