Epsilon Aminocaproic Acid (EACA) for the Reduction of Blood Loss in Total Hip Arthroplasty (THA)
Study type: Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Scottsdale/Phoenix, Arizona: 11-001111
- Jacksonville, Florida: 11-001111
NCT ID: NCT01391182
Sponsor Protocol Number: 11-001111
About this study
You are being asked to take part in this research study because you are scheduled to have total hip replacement (arthroplasty) surgery. The goal of this study is to evaluate the effectiveness of the drug, epsilon Aminocaproic Acid (EACA), in decreasing the need for patients to receive blood after surgery. Currently, EACA is approved by the Federal Drug Administration (FDA) to treat a patient who is bleeding. The investigators plan to use EACA to prevent bleeding during and after surgery; use of this drug as a means of preventing bleeding is not currently approved by the FDA.
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.
See eligibility criteria
This study is enrolling participants by invitation only.
- Scheduled for a primary total hip arthroplasty to be performed at the Mayo Clinic
- A preoperative hemoglobin between 10.0 and 13.5
- A preoperative hemoglobin less than 10.0 or greater than 13.5
- Revision arthroplasty;
- Arthroplasty performed for acute fracture
- Inability to obtain informed consent;
- Allergy to EACA
- History of coronary stenting < 6 months
- Heart valve replacement;
- Renal disease,
- Coagulopathy, DIC,
- embolic stroke
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.