Sleep Apnea and Vascular Function

  • Study type:

    Interventional What is this?

    Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

Study IDs

  • Site IRB:

    • Rochester, Minnesota: 12-006285
  • NCT ID:

    NCT01717339
  • Sponsor Protocol Number:

    12-006285

About this study

Obstructive sleep apnea (OSA) is associated with endothelial dysfunction and the development of cardiovascular disease. It is unclear how OSA results in endothelial dysfunction, but given the association between OSA and obesity, adipose-derived hormones (adipokines) are likely to be involved. Leptin, an adipokine upregulated in patients with OSA, has been shown to be associated with deleterious effects on vascular function resulting in impaired endothelial function. This proposal is directed at investigating the molecular mechanisms of endothelial dysfunction in OSA patients. We hypothesize that endothelial dysfunction associated with OSA is a result of molecular alterations within endothelial cells. As a part of these studies we will look at NO signaling pathways in adipose tissue and microvessels from normal and OSA subjects.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Non OSA, and newly diagnosed OSA subjects
  • Naïve to CPAP treatment
  • Aged 20-55 years
  • With BMI less than 40 kg/m2, who are free of all chronic diseases including hypertension, diabetes, and cardiovascular diseases

Exclusion Criteria:

  • Pregnancy.
  • Anemic (hemoglobin <13.5 g/dL for men and <12.0 g/dL for women.
  • Postmenopausal
  • Smoking
  • Use of chronic Medications (aspirin, beta agonist, anti-inflammatory drugs)

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Virend Somers, M.D., Ph.D.

Contact us for the latest status

Diane Davison R.N., CCRP

(507)255-8794

Davison.Diane@mayo.edu